Iodoquinol: Difference between revisions
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==Overview== | ==Overview== | ||
The [[quinoline]] derivative '''diiodohydroxyquinoline''' ([[International Nonproprietary Name|INN]]) or '''iodoquinol''' ([[United States Adopted Name|USAN]]), can be used in the treatment of [[amoebiasis]].<ref name="pmid2493578">{{cite journal |author=Ghaskadbi S, Vaidya VG |title=In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline |journal=Mutat. Res. |volume=222 |issue=3 |pages=219–22 |year=1989 |month=March |pmid=2493578 |doi= 10.1016/0165-1218(89)90137-7|url=}}</ref> It is poorly absorbed from the [[gastrointestinal tract]] and is used as a luminal amebicide. It acts by [[chelation]] of [[ferrous ion]]s essential for metabolism.<ref>{{cite web|url=http://web.gideononline.com/web/therapy/index.php?type=drugs&code=20130&view=General |work=Gideon Online}}</ref> It was discovered by Adco Co. and introduced as ''diiodohydroxyquinoline''.<ref>Page 1312. http://books.google.co.in/books?id=TIu28TH_iAYC&printsec=frontcover&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false</ref> Susceptibility of ''[[Dientamoeba fragilis]]'' has been measured.<ref name="pmid8067755">{{cite journal |author=Chan FT, Guan MX, Mackenzie AM, Diaz-Mitoma F |title=Susceptibility testing of Dientamoeba fragilis ATCC 30948 with iodoquinol, paromomycin, tetracycline, and metronidazole |journal=Antimicrob. Agents Chemother. |volume=38 |issue=5 |pages=1157–60 |year=1994 |month=May |pmid=8067755 |pmc=188168 |doi= |url=http://aac.asm.org/cgi/pmidlookup?view=long&pmid=8067755}}</ref> | |||
==Category== | ==Category== | ||
Revision as of 19:29, 23 December 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The quinoline derivative diiodohydroxyquinoline (INN) or iodoquinol (USAN), can be used in the treatment of amoebiasis.[1] It is poorly absorbed from the gastrointestinal tract and is used as a luminal amebicide. It acts by chelation of ferrous ions essential for metabolism.[2] It was discovered by Adco Co. and introduced as diiodohydroxyquinoline.[3] Susceptibility of Dientamoeba fragilis has been measured.[4]
Category
Amebicide
US Brand Names
ALA-SEPTIC®, ALCORTIN®, ALCORTIN A®, ALOQUIN®, DERMAZENE®, HYDROCORTISONE IODOQUINOL cream®, VYTONE cream®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings | Precautions | Adverse Reactions | Overdosage | Clinical Studies | Dosage and Administration | Compatibility, Reconstitution, and Stability | Directions For Use | How Supplied | Other Size Packages Available | Labels and Packages
Mechanisms of Action
References
- ↑ Ghaskadbi S, Vaidya VG (1989). "In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline". Mutat. Res. 222 (3): 219–22. doi:10.1016/0165-1218(89)90137-7. PMID 2493578. Unknown parameter
|month=ignored (help) - ↑ Gideon Online http://web.gideononline.com/web/therapy/index.php?type=drugs&code=20130&view=General. Missing or empty
|title=(help) - ↑ Page 1312. http://books.google.co.in/books?id=TIu28TH_iAYC&printsec=frontcover&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false
- ↑ Chan FT, Guan MX, Mackenzie AM, Diaz-Mitoma F (1994). "Susceptibility testing of Dientamoeba fragilis ATCC 30948 with iodoquinol, paromomycin, tetracycline, and metronidazole". Antimicrob. Agents Chemother. 38 (5): 1157–60. PMC 188168. PMID 8067755. Unknown parameter
|month=ignored (help)