Ethambutol: Difference between revisions
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==Mechanism of | |||
==Mechanism of action== | |||
Ethambutol is [[bacteriostatic]] against actively growing TB bacilli. It works by obstructing the formation of [[cell wall]]. [[Mycolic acid]]s attach to the 5'-hydroxyl groups of [[arabinose|<small>D</small>-arabinose]] residues of [[arabinogalactan]] and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. It disrupts arabinogalactan synthesis by inhibiting the enzyme [[arabinosyl transferase]]. Disruption of the arabinogalactan synthesis inhibits the formation of this complex and leads to increased permeability of the cell wall. | |||
==References== | ==References== | ||
Revision as of 13:12, 27 December 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
MYAMBUTOLEthambutol (commonly abbreviated EMB or simply E) is a bacteriostatic antimycobacterial drug prescribed to treat tuberculosis.[1] It is usually given in combination with other tuberculosis drugs, such as isoniazid, rifampicin and pyrazinamide.
It is sold under the trade names Myambutol and Servambutol.
Category
Antimycobacterial
US Brand Names
MYAMBUTOL
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Overdosage | Clinical Studies | Dosage and Administration | Compatibility, Reconstitution, and Stability | Directions For Use | How Supplied | Labels and Packages
Mechanism of action
Ethambutol is bacteriostatic against actively growing TB bacilli. It works by obstructing the formation of cell wall. Mycolic acids attach to the 5'-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. It disrupts arabinogalactan synthesis by inhibiting the enzyme arabinosyl transferase. Disruption of the arabinogalactan synthesis inhibits the formation of this complex and leads to increased permeability of the cell wall.
References
- ↑ Yendapally R, Lee RE (2008). "Design, synthesis, and evaluation of novel ethambutol analogues". Bioorg. Med. Chem. Lett. 18 (5): 1607–11. doi:10.1016/j.bmcl.2008.01.065. PMC 2276401. PMID 18242089. Unknown parameter
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