Renal cell carcinoma classification: Difference between revisions
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==Overview== | ==Overview== | ||
==Classification== | ==Classification== | ||
The following tables classify renal cell carcinoma according to histologic appearance and differentiates sporadic from hereditary forms of renal cell carcinoma. | |||
{| border="1" style="border-collapse:collapse; text-align:left;" cellpadding="5" align="center" | |||
|+ '''''Sporadic Forms of Renal Cell Carcinoma<ref name="pmid16339096">{{cite journal| author=Cohen HT, McGovern FJ| title=Renal-cell carcinoma. | journal=N Engl J Med | year= 2005 | volume= 353 | issue= 23 | pages= 2477-90 | pmid=16339096 | doi=10.1056/NEJMra043172 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16339096 }} </ref>''''' | |||
| bgcolor="#ececec"|'''Histologic Appearance''' || '''Incidence''' || '''Gene'''|| '''Frequency''' | |||
|- | |||
| bgcolor="#ececec"|''Conventional'' || 75 || VHL|| 60 % | |||
|- | |||
| bgcolor="#ececec"|'''Papillary''' || 12|| MET <br> TFE3|| 13 %<br> < 1 % | |||
|- | |||
| bgcolor="#ececec"|'''Chromophobe''' || 4 % | |||
|- | |||
| bgcolor="#ececec"|'''Oncocytoma''' || 4 % | |||
|- | |||
|bgcolor="#ececec"|'''Collecting Duct''' || < 1 % | |||
|- | |||
|bgcolor="#ececec"|'''Unclassified''' || 3 - 5 % | |||
|} | |||
<sup><center>Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.''N Engl J Med''. 2005; 353:2477-90</center></sup> | |||
{| border="1" style="border-collapse:collapse; text-align:left;" cellpadding="5" align="center" | |||
|+ '''''Hereditary Forms of Renal Cell Carcinoma<ref name="pmid16339096">{{cite journal|author=Cohen HT, McGovern FJ| title=Renal-cell carcinoma. | journal=N Engl J Med |year= 2005 | volume= 353 | issue= 23 | pages= 2477-90 | pmid=16339096 |doi=10.1056/NEJMra043172 | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16339096 }}</ref>''''' | |||
| bgcolor="#ececec"|'''Syndrome''' || '''Associated Gene''' || Common Histological Appearance | |||
|- | |||
| bgcolor="#ececec"|''VHL Disease'' || VHL || Conventional | |||
|- | |||
| bgcolor="#ececec"|'''FCRC''' || Chromosome 3p translocation || Conventional | |||
|- | |||
| bgcolor="#ececec"|'''Hereditary paraganglioma''' || SDHB || Conventional | |||
|- | |||
| bgcolor="#ececec"|'''HPRC''' || MET || Papillary | |||
|- | |||
| bgcolor="#ececec"|'''HLRCC''' || FH || Papillary | |||
|- | |||
|bgcolor="#ececec"|'''Birt-Hogg-Dube Syndrome''' || BHD || Chromophobe / Oncocytoma | |||
|} | |||
<sup><center>Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.''N Engl J Med''. 2005; 353:2477-90</center></sup> | |||
* [[Clear cell carcinoma]] ([[Von Hippel-Lindau tumor suppressor|VHL]] and others on [[chromosome 3]]) | * [[Clear cell carcinoma]] ([[Von Hippel-Lindau tumor suppressor|VHL]] and others on [[chromosome 3]]) |
Revision as of 16:09, 27 December 2013
Renal cell carcinoma Microchapters |
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Risk calculators and risk factors for Renal cell carcinoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Classification
The following tables classify renal cell carcinoma according to histologic appearance and differentiates sporadic from hereditary forms of renal cell carcinoma.
Histologic Appearance | Incidence | Gene | Frequency |
Conventional | 75 | VHL | 60 % |
Papillary | 12 | MET TFE3 |
13 % < 1 % |
Chromophobe | 4 % | ||
Oncocytoma | 4 % | ||
Collecting Duct | < 1 % | ||
Unclassified | 3 - 5 % |
Syndrome | Associated Gene | Common Histological Appearance |
VHL Disease | VHL | Conventional |
FCRC | Chromosome 3p translocation | Conventional |
Hereditary paraganglioma | SDHB | Conventional |
HPRC | MET | Papillary |
HLRCC | FH | Papillary |
Birt-Hogg-Dube Syndrome | BHD | Chromophobe / Oncocytoma |
- Clear cell carcinoma (VHL and others on chromosome 3)
- Papillary carcinoma (MET, PRCC)
- Chromophobe renal carcinoma
- Collecting duct carcinoma
References
- ↑ 1.0 1.1 Cohen HT, McGovern FJ (2005). "Renal-cell carcinoma". N Engl J Med. 353 (23): 2477–90. doi:10.1056/NEJMra043172. PMID 16339096.