Renal cell carcinoma classification: Difference between revisions

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|+ '''''Sporadic Forms of Renal Cell Carcinoma<ref name="pmid16339096">{{cite journal| author=Cohen HT, McGovern FJ| title=Renal-cell carcinoma. | journal=N Engl J Med | year= 2005 | volume= 353 | issue= 23 | pages= 2477-90 | pmid=16339096 | doi=10.1056/NEJMra043172 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16339096  }} </ref>'''''
|+ '''''Sporadic Forms of Renal Cell Carcinoma<ref name="pmid16339096">{{cite journal| author=Cohen HT, McGovern FJ| title=Renal-cell carcinoma. | journal=N Engl J Med | year= 2005 | volume= 353 | issue= 23 | pages= 2477-90 | pmid=16339096 | doi=10.1056/NEJMra043172 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16339096  }} </ref>'''''
| bgcolor="#ececec"|'''Histologic Appearance''' || '''Incidence''' || '''Gene'''|| '''Frequency'''
| bgcolor="#d9ff54"|'''Histologic Appearance''' || bgcolor="#d9ff54"|'''Incidence'''||bgcolor="#d9ff54"|'''Gene'''||bgcolor="#d9ff54"|'''Frequency'''
|-
| bgcolor="#ececec"|'''Conventional''' || 75 || VHL|| 60 %  
| bgcolor="#ececec"|''Conventional'' || 75 || VHL|| 60 %  
|-
|-
| bgcolor="#ececec"|'''Papillary''' || 12|| MET <br> TFE3|| 13 %<br> < 1 %
| bgcolor="#ececec"|'''Papillary''' || 12|| MET <br> TFE3|| 13 %<br> < 1 %
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|+ '''''Hereditary Forms of Renal Cell Carcinoma<ref name="pmid16339096">{{cite journal|author=Cohen HT, McGovern FJ| title=Renal-cell carcinoma. | journal=N Engl J Med |year= 2005 | volume= 353 | issue= 23 | pages= 2477-90 | pmid=16339096 |doi=10.1056/NEJMra043172 | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16339096  }}</ref>'''''
|+ '''''Hereditary Forms of Renal Cell Carcinoma<ref name="pmid16339096">{{cite journal|author=Cohen HT, McGovern FJ| title=Renal-cell carcinoma. | journal=N Engl J Med |year= 2005 | volume= 353 | issue= 23 | pages= 2477-90 | pmid=16339096 |doi=10.1056/NEJMra043172 | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16339096  }}</ref>'''''
| bgcolor="#ececec"|'''Syndrome''' || '''Associated Gene''' || Common Histological Appearance
 
 
| bgcolor="#d9ff54"|'''Syndrome''' || bgcolor="#d9ff54"|'''Associated Gene'''||bgcolor="#d9ff54"|''''''Common Histological Appearance'''||bgcolor="#d9ff54"|'''Characteristic Features'''
|-
|-
| bgcolor="#ececec"|''VHL Disease'' || VHL || Conventional
| bgcolor="#ececec"|'''VHL Disease''' || VHL || Conventional
|-
|-
| bgcolor="#ececec"|'''FCRC''' || Chromosome 3p translocation || Conventional
| bgcolor="#ececec"|'''FCRC''' || Chromosome 3p translocation || Conventional

Revision as of 16:15, 27 December 2013

Renal cell carcinoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Classification

The following tables classify renal cell carcinoma according to histologic appearance and differentiates sporadic from hereditary forms of renal cell carcinoma.

Sporadic Forms of Renal Cell Carcinoma[1]
Histologic Appearance Incidence Gene Frequency Conventional 75 VHL 60 %
Papillary 12 MET
TFE3		 13 %
< 1 %
Chromophobe 4
Oncocytoma 4
Collecting Duct < 1
Unclassified 3 - 5
Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.N Engl J Med. 2005; 353:2477-90


Hereditary Forms of Renal Cell Carcinoma[1]
Syndrome Associated Gene 'Common Histological Appearance Characteristic Features
VHL Disease VHL Conventional
FCRC Chromosome 3p translocation Conventional
Hereditary paraganglioma SDHB Conventional
HPRC MET Papillary
HLRCC FH Papillary
Birt-Hogg-Dube Syndrome BHD Chromophobe / Oncocytoma
Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.N Engl J Med. 2005; 353:2477-90


References

  1. ↑ 1.0 1.1 Cohen HT, McGovern FJ (2005). "Renal-cell carcinoma". N Engl J Med. 353 (23): 2477–90. doi:10.1056/NEJMra043172. PMID 16339096.


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