Renal cell carcinoma classification: Difference between revisions
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==Overview== | ==Overview== | ||
==Classification== | ==Classification== | ||
===Sporadic vs. Hereditary=== | |||
The following tables classify renal cell carcinoma according to histologic appearance and differentiates sporadic from hereditary forms of renal cell carcinoma. | The following tables classify renal cell carcinoma according to histologic appearance and differentiates sporadic from hereditary forms of renal cell carcinoma. | ||
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| bgcolor="#d9ff54"|'''Syndrome''' || bgcolor="#d9ff54"|'''Associated Gene'''||bgcolor="#d9ff54"| | | bgcolor="#d9ff54"|'''Syndrome''' || bgcolor="#d9ff54"|'''Associated Gene'''||bgcolor="#d9ff54"|'''Common Histological Appearance''' | ||
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| bgcolor="#ececec"|'''VHL Disease''' || VHL || Conventional | | bgcolor="#ececec"|'''VHL Disease''' || VHL || Conventional | ||
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| bgcolor="#ececec"|'''FCRC''' || Chromosome 3p translocation || Conventional | | bgcolor="#ececec"|'''FCRC''' || Chromosome 3p translocation || Conventional | ||
|- | |- | ||
| bgcolor="#ececec"|'''Hereditary | | bgcolor="#ececec"|'''Hereditary Paraganglioma''' || SDHB || Conventional | ||
|- | |- | ||
| bgcolor="#ececec"|'''HPRC''' || MET || Papillary | | bgcolor="#ececec"|'''HPRC''' || MET || Papillary | ||
Revision as of 16:17, 27 December 2013
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Renal cell carcinoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Renal cell carcinoma classification On the Web |
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American Roentgen Ray Society Images of Renal cell carcinoma classification |
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Risk calculators and risk factors for Renal cell carcinoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Classification
Sporadic vs. Hereditary
The following tables classify renal cell carcinoma according to histologic appearance and differentiates sporadic from hereditary forms of renal cell carcinoma.
| Histologic Appearance | Incidence | Gene | Frequency |
| Conventional | 75 | VHL | 60 % |
| Papillary | 12 | MET TFE3 |
13 % < 1 % |
| Chromophobe | 4 | ||
| Oncocytoma | 4 | ||
| Collecting Duct | < 1 | ||
| Unclassified | 3 - 5 |
| Syndrome | Associated Gene | Common Histological Appearance |
| VHL Disease | VHL | Conventional |
| FCRC | Chromosome 3p translocation | Conventional |
| Hereditary Paraganglioma | SDHB | Conventional |
| HPRC | MET | Papillary |
| HLRCC | FH | Papillary |
| Birt-Hogg-Dube Syndrome | BHD | Chromophobe / Oncocytoma |
- Clear cell carcinoma (VHL and others on chromosome 3)
- Papillary carcinoma (MET, PRCC)
- Chromophobe renal carcinoma
- Collecting duct carcinoma
References
- ↑ 1.0 1.1 Cohen HT, McGovern FJ (2005). "Renal-cell carcinoma". N Engl J Med. 353 (23): 2477–90. doi:10.1056/NEJMra043172. PMID 16339096.