Cefazolin sodium: Difference between revisions
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==Mechanism of Action== | ==Mechanism of Action== | ||
Cefazolin sodium belongs to the first-genaration [[Cephalosporins]].[[Cephalosporins]] are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). [[Cephalosporins]] disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as [[penicillin]] binding proteins (PBPs) | |||
==References== | ==References== | ||
Revision as of 16:43, 27 December 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic.
The drug is usually administrated either by intramuscular injection (injection into a large muscle) or intravenous infusion (intravenous fluid into a vein).
Category
Cephalosporin,First-Generation
US Brand Names
ANCEF®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Clinical Studies | Dosage and Administration | Compatibility, Reconstitution, and Stability | Directions For Use | How Supplied | Labels and Packages
Mechanism of Action
Cefazolin sodium belongs to the first-genaration Cephalosporins.Cephalosporins are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin binding proteins (PBPs)