Cefazolin sodium: Difference between revisions

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==Mechanism of Action==
==Mechanism of Action==
Cefazolin sodium belongs to the first-genaration [[Cephalosporins]].[[Cephalosporins]] are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). [[Cephalosporins]] disrupt the synthesis of the [[peptidoglycan ]]layer of bacterial cell walls. The [[peptidoglycan ]]layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the [[peptidoglycan ]]is facilitated by transpeptidases known as [[penicillin]] binding proteins (PBPs)
Cefazolin sodium belongs to the first-genaration [[Cephalosporins]].[[Cephalosporins]] are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as [[penicillins]]). [[Cephalosporins]] disrupt the synthesis of the [[peptidoglycan ]]layer of bacterial cell walls. The [[peptidoglycan ]]layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the [[peptidoglycan ]]is facilitated by transpeptidases known as [[penicillins]] binding proteins (PBPs)


==References==
==References==

Revision as of 16:45, 27 December 2013

Cefazolin Sodium
CEFAZOLIN® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Dosage and Administration
Compatibility, Reconstitution, and Stability
How Supplied
Labels and Packages

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic.

The drug is usually administrated either by intramuscular injection (injection into a large muscle) or intravenous infusion (intravenous fluid into a vein).

Category

Cephalosporin,First-Generation

US Brand Names

ANCEF®

FDA Package Insert

Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Clinical Studies | Dosage and Administration | Compatibility, Reconstitution, and Stability | Directions For Use | How Supplied | Labels and Packages

Mechanism of Action

Cefazolin sodium belongs to the first-genaration Cephalosporins.Cephalosporins are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillins binding proteins (PBPs)

References