Abacavir: Difference between revisions
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==Overview== | ==Overview== | ||
'''Abacavir''' ('''ABC''') {{IPAc-en|audio=en-abacavir.ogg|ʌ|.|b|æ|k|.|ʌ|.|v|ɪər}} is a [[nucleoside]] analog [[reverse transcriptase inhibitor]] (NRTI) used to treat [[HIV]] and [[AIDS]]. It is available under the trade name '''Ziagen''' ([[ViiV Healthcare]]) and in the combination formulations '''Trizivir''' (abacavir, [[zidovudine]] and [[lamivudine]]) and '''Kivexa'''/'''Epzicom''' (abacavir and lamivudine). It has been well tolerated: the main side effect is [[hypersensitivity]], which can be severe, and in rare cases, fatal. Genetic testing can indicate whether an individual will be hypersensitive; over 90% of patients can safely take abacavir. However, in a separate study, the risk of heart attack increased by nearly 90%.<ref>[http://www.sfgate.com/cgi-bin/article.cgi?f=/c/a/2008/04/02/MNE2VU4TF.DTL SFGate.com]</ref> | |||
Viral strains that are resistant to [[zidovudine]] (AZT) ''or'' [[lamivudine]] (3TC) are generally sensitive to abacavir (ABC), whereas some strains that are resistant to AZT ''and'' 3TC are not as sensitive to abacavir. | |||
==Category== | ==Category== | ||
Revision as of 19:36, 30 December 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Abacavir (ABC) Lua error: expandTemplate: template "Template:IPA audio link" does not exist. is a nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. It is available under the trade name Ziagen (ViiV Healthcare) and in the combination formulations Trizivir (abacavir, zidovudine and lamivudine) and Kivexa/Epzicom (abacavir and lamivudine). It has been well tolerated: the main side effect is hypersensitivity, which can be severe, and in rare cases, fatal. Genetic testing can indicate whether an individual will be hypersensitive; over 90% of patients can safely take abacavir. However, in a separate study, the risk of heart attack increased by nearly 90%.[1]
Viral strains that are resistant to zidovudine (AZT) or lamivudine (3TC) are generally sensitive to abacavir (ABC), whereas some strains that are resistant to AZT and 3TC are not as sensitive to abacavir.
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US Brand Names
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Overdosage | Clinical Studies | Dosage and Administration | Compatibility, Reconstitution, and Stability | Directions For Use | How Supplied | Labels and Packages