Valacyclovir description: Difference between revisions
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Revision as of 19:49, 30 December 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Description
VALTREX (valacyclovir hydrochloride) is the hydrochloride salt of the L─valyl ester of the antiviral drug acyclovir.
VALTREX Caplets are for oral administration. Each caplet contains valacyclovir hydrochloride equivalent to 500 mg or 1 gram valacyclovir and the inactive ingredients carnauba wax, colloidal silicon dioxide, crospovidone, FD&C Blue No. 2 Lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, povidone, and titanium dioxide. The blue, film─coated caplets are printed with edible white ink.
The chemical name of valacyclovir hydrochloride is L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester, monohydrochloride. It has the following structural formula:
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Valacyclovir hydrochloride is a white to off─white powder with the molecular formula C13H20N6O4•HCl and a molecular weight of 360.80. The maximum solubility in water at 25°C is 174 mg/mL. The pkas for valacyclovir hydrochloride are 1.90, 7.47, and 9.43.[1]
References
- ↑ "http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020487s014lbl.pdf" (PDF). External link in
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Adapted from the FDA Package Insert.