Ampicillin clinical pharmacology: Difference between revisions
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==Clinical Pharmacology== | ==Clinical Pharmacology== | ||
Ampicillin for Injection, USP diffuses readily into most body tissues and fluids. However, penetration into the cerebrospinal fluid and brain occurs only when the meninges are inflamed. Ampicillin is excreted largely unchanged in the urine and its excretion can be delayed by concurrent administration of probenecid. The active form appears in the bile in higher concentrations than those found in serum. Ampicillin is the least serum-bound of all the penicillins, averaging about 20% compared to approximately 60 to 90% for other penicillins. Ampicillin for Injection, USP is well tolerated by most patients and has been given in doses of 2 grams daily for many weeks without adverse reactions.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = AMPICILLIN (AMPICILLIN SODIUM) INJECTION, POWDER, FOR SOLUTION AMPICILLIN (AMPICILLIN SODIUM) INJECTION, POWDER, FOR SOLUTION [CLARIS LIFESCIENCES, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=da8da9c0-fa46-40d3-82c6-1a18ffa1b585 | publisher = | date = | accessdate | Ampicillin for Injection, USP diffuses readily into most body tissues and fluids. However, penetration into the cerebrospinal fluid and brain occurs only when the meninges are inflamed. Ampicillin is excreted largely unchanged in the urine and its excretion can be delayed by concurrent administration of probenecid. The active form appears in the bile in higher concentrations than those found in serum. Ampicillin is the least serum-bound of all the penicillins, averaging about 20% compared to approximately 60 to 90% for other penicillins. Ampicillin for Injection, USP is well tolerated by most patients and has been given in doses of 2 grams daily for many weeks without adverse reactions.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = AMPICILLIN (AMPICILLIN SODIUM) INJECTION, POWDER, FOR SOLUTION AMPICILLIN (AMPICILLIN SODIUM) INJECTION, POWDER, FOR SOLUTION [CLARIS LIFESCIENCES, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=da8da9c0-fa46-40d3-82c6-1a18ffa1b585 | publisher = | date = | accessdate}}</ref> | ||
==References== | ==References== | ||
Latest revision as of 20:57, 30 December 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]
Clinical Pharmacology
Ampicillin for Injection, USP diffuses readily into most body tissues and fluids. However, penetration into the cerebrospinal fluid and brain occurs only when the meninges are inflamed. Ampicillin is excreted largely unchanged in the urine and its excretion can be delayed by concurrent administration of probenecid. The active form appears in the bile in higher concentrations than those found in serum. Ampicillin is the least serum-bound of all the penicillins, averaging about 20% compared to approximately 60 to 90% for other penicillins. Ampicillin for Injection, USP is well tolerated by most patients and has been given in doses of 2 grams daily for many weeks without adverse reactions.[1]
References
Adapted from the FDA Package Insert.