Spectinomycin microbiology: Difference between revisions
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==Microbiology== | ==Microbiology== | ||
Spectinomycin hydrochloride is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. | Spectinomycin hydrochloride is an inhibitor of protein synthesis in the bacterial cell; the site of action is the [[30S]] ribosomal subunit. | ||
In vitro studies have shown spectinomycin hydrochloride to be active against most strains of [[Neisseria gonorrhoeae]] (minimum inhibitory concentration <7.5 to 20 mcg/mL). | In vitro studies have shown spectinomycin hydrochloride to be active against most strains of ''[[Neisseria gonorrhoeae]]'' (minimum inhibitory concentration <7.5 to 20 mcg/mL). | ||
Definitive in vitro studies have shown no cross-resistance of N. gonorrhoeae between spectinomycin hydrochloride and penicillin. The antibiotic is not significantly bound to plasma protein.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = TROBICIN (SPECTINOMYCIN) [PHARMACIA AND UPJOHN, CO.] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=becf7b7a-508c-44ff-add0-558a60fd0067 | publisher = | date = | accessdate = }}</ref> | Definitive in vitro studies have shown no cross-resistance of N. gonorrhoeae between spectinomycin hydrochloride and penicillin. The antibiotic is not significantly bound to plasma protein.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = TROBICIN (SPECTINOMYCIN) [PHARMACIA AND UPJOHN, CO.] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=becf7b7a-508c-44ff-add0-558a60fd0067 | publisher = | date = | accessdate = }}</ref> | ||
Latest revision as of 00:52, 31 December 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Microbiology
Spectinomycin hydrochloride is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit.
In vitro studies have shown spectinomycin hydrochloride to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Definitive in vitro studies have shown no cross-resistance of N. gonorrhoeae between spectinomycin hydrochloride and penicillin. The antibiotic is not significantly bound to plasma protein.[1]
References
Adapted from the FDA Package Insert.