Entecavir: Difference between revisions

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{{drugbox
__NOTOC__
| IUPAC_name = 2-amino-9-<nowiki>[</nowiki>4-hydroxy-3-(hydroxymethyl)-<br />2-methylidene-cyclopentyl<nowiki>]</nowiki>-3''H''-purin-6-one
{{XXXXX}}
| image = Entecavir structure.svg
{{CMG}}
| CAS_number = 142217-69-4
 
| ATC_prefix = J05
==Overview==
| ATC_suffix = AF10
| ATC_supplemental =
| PubChem = 153941
| DrugBank = APRD00948
| C=12 | H=15 | N=5 | O=3
| molecular_weight = 277.279 g/mol
| bioavailability =
| protein_bound = 13%
| metabolism =  
| elimination_half-life = 128–149 hours
| excretion = Renal 62–73%
| pregnancy_US = C
| legal_US = Rx-only
| routes_of_administration = Oral
| licence_EU =Baraclude
| licence_US =Entecavir
}}
'''Entecavir''' ([[International Nonproprietary Name|INN]]) ({{pronEng|ɛnˈtɛkəvɪr}}) is an oral [[antiviral drug]] used in the treatment of [[hepatitis B]] infection. It is marketed under the trade name '''Baraclude''' ([[Bristol-Myers Squibb|BMS]]).
'''Entecavir''' ([[International Nonproprietary Name|INN]]) ({{pronEng|ɛnˈtɛkəvɪr}}) is an oral [[antiviral drug]] used in the treatment of [[hepatitis B]] infection. It is marketed under the trade name '''Baraclude''' ([[Bristol-Myers Squibb|BMS]]).


Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B ([[lamivudine]] and [[adefovir]]). It was approved by the U.S. [[Food and Drug Administration]] (FDA) in March 2005.
Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B ([[lamivudine]] and [[adefovir]]). It was approved by the U.S. [[Food and Drug Administration]] (FDA) in March 2005.


==External links==
==Category==
*[http://www.baraclude.com/ Baraclude U.S. website]
Antiviral
 
 
==US Brand Names==
BARACLUDE<sup>®</sup>
 
 
==FDA Package Insert==
 
'''  [[XXXXX description|Description]]'''
'''| [[XXXXX clinical pharmacology|Clinical Pharmacology]]'''
'''| [[XXXXX microbiology|Microbiology]]'''
'''| [[XXXXX indications and usage|Indications and Usage]]'''
'''| [[XXXXX contraindications|Contraindications]]'''
'''| [[XXXXX warnings and precautions|Warnings and Precautions]]'''
'''| [[XXXXX adverse reactions|Adverse Reactions]]'''
'''| [[XXXXX drug interactions|Drug Interactions]]'''
'''| [[XXXXX overdosage|Overdosage]]'''
'''| [[XXXXX clinical studies|Clinical Studies]]'''
'''| [[XXXXX dosage and administration|Dosage and Administration]]'''
'''| [[XXXXX how supplied|How Supplied]]'''
'''| [[XXXXX labels and packages|Labels and Packages]]'''
 
==Mechanism of Action==
 
 


[[Category:Antivirals]]
==References==


{{pharma-stub}}
{{Reflist|2}}


[[de:Entecavir]]
[[Category:Antibiotics]]
{{WikiDoc Sources}}
[[Category:Wikinfect]]

Revision as of 16:30, 3 January 2014


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Entecavir (INN) (Template:PronEng) is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS).

Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). It was approved by the U.S. Food and Drug Administration (FDA) in March 2005.

Category

Antiviral


US Brand Names

BARACLUDE®


FDA Package Insert

Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Clinical Studies | Dosage and Administration | How Supplied | Labels and Packages

Mechanism of Action

References

Retrieved from "https://www.wikidoc.org/index.php?title=Entecavir&oldid=923655"