Achalasia overview: Difference between revisions
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==Overview== | ==Overview== | ||
'''Achalasia''' is an [[esophageal motility disorder]].<ref name=Kraichely_2006>{{cite journal |author=Kraichely R, Farrugia G |title=Achalasia: physiology and etiopathogenesis |journal=Dis Esophagus |volume=19 |issue=4 |pages=213-23 |year=2006 |pmid=16866850}}</ref> In this disorder, the [[smooth muscle cell|smooth muscle]] layer of the [[esophagus]] has impaired [[peristalsis]] (muscular ability to move food down the esophagus), and the [[lower esophageal sphincter]] (LES) fails to relax properly in response to [[swallowing]].<ref name=Park_2005>{{cite journal |author=Park W, Vaezi M |title=Etiology and pathogenesis of achalasia: the current understanding |journal=Am J Gastroenterol |volume=100 |issue=6 |pages=1404-14 |year=2005 |pmid=15929777}}</ref> The most common form is | '''Achalasia''' is an [[esophageal motility disorder]].<ref name=Kraichely_2006>{{cite journal |author=Kraichely R, Farrugia G |title=Achalasia: physiology and etiopathogenesis |journal=Dis Esophagus |volume=19 |issue=4 |pages=213-23 |year=2006 |pmid=16866850}}</ref> In this disorder, the [[smooth muscle cell|smooth muscle]] layer of the [[esophagus]] has impaired [[peristalsis]] (muscular ability to move food down the esophagus), and the [[lower esophageal sphincter]] (LES) fails to relax properly in response to [[swallowing]] due to absent enteric neurons.<ref name=Park_2005>{{cite journal |author=Park W, Vaezi M |title=Etiology and pathogenesis of achalasia: the current understanding |journal=Am J Gastroenterol |volume=100 |issue=6 |pages=1404-14 |year=2005 |pmid=15929777}}</ref> The most common form is idiopathic achalasia, which has no known underlying cause. However, a small proportion occurs as a secondary result of other conditions, such as [[esophageal cancer]] or (in South America) [[Chagas disease]]. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 02:51, 5 January 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Achalasia is an esophageal motility disorder.[1] In this disorder, the smooth muscle layer of the esophagus has impaired peristalsis (muscular ability to move food down the esophagus), and the lower esophageal sphincter (LES) fails to relax properly in response to swallowing due to absent enteric neurons.[2] The most common form is idiopathic achalasia, which has no known underlying cause. However, a small proportion occurs as a secondary result of other conditions, such as esophageal cancer or (in South America) Chagas disease.