Penicillin V potassium: Difference between revisions
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==Overview== | ==Overview== | ||
'''Phenoxymethylpenicillin''', commonly known as penicillin V, is a [[penicillin]] antibiotic that is orally active. It is less active than [[benzylpenicillin]] (penicillin G) against [[Gram-negative bacteria]].<ref name="Garrod1960"> | |||
{{cite journal | |||
| author = Garrod, L. P. | |||
| title = Relative Antibacterial Activity of Three Penicillins | |||
| journal = British Medical Journal | |||
| year = 1960 | |||
| issue = 5172 | |||
| pages = 527–29 | |||
}}</ref><ref name="Garrod1960a"> | |||
{{cite journal | |||
| author = Garrod, L. P. | |||
| title = The Relative Antibacterial Activity of Four Penicillins | |||
| journal = British Medical Journal | |||
| year = 1960 | |||
| issue = 5214 | |||
| pages = 1695–6 | |||
}}</ref> Phenoxymethylpenicillin is more acid-stable than benzylpenicillin, which allows it to be given orally. It exerts a [[Bactericidal#Bactericidal_antibiotics|bactericidal]] action against penicillin-sensitive microorganisms during the stage of active multiplication. It acts by [[enzyme inhibitor|inhibiting]] the [[protein biosynthesis|biosynthesis]] of cell-wall [[peptidoglycan]]. It is not active against [[beta-lactamase]]-producing bacteria, which include many strains of ''[[staphylococcus|Staphylococci]]''.<ref name="DailyMed">{{cite web|url=http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=645|title=Penicillin V Potassium tablet: Drug Label Sections|date=12/2006|publisher=[[United States National Library of Medicine|U.S. National Library of Medicine]], [[Daily Med]]: Current Medication Information|accessdate=2009-08-02}}</ref> | |||
Phenoxymethylpenicillin has a range of antimicrobial activity against [[Gram-positive bacteria]] that is similar to that of benzylpenicillin and a similar mode of action, but it is substantially less active than benzylpenicillin against [[Gram-negative bacteria]].<ref name="Garrod1960" /><ref name="Garrod1960a" /> | |||
==Category== | ==Category== | ||
Revision as of 03:38, 5 January 2014
| Penicillin V potassium |
|---|
| PENICILLIN V POTASSIUM® FDA Package Insert |
| Description |
| Clinical Pharmacology |
| Indications and Usage |
| Contraindications |
| Warnings and Precautions |
| Adverse Reactions |
| Dosage and Administration |
| How Supplied |
| Labels and Packages |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]
Overview
Phenoxymethylpenicillin, commonly known as penicillin V, is a penicillin antibiotic that is orally active. It is less active than benzylpenicillin (penicillin G) against Gram-negative bacteria.[1][2] Phenoxymethylpenicillin is more acid-stable than benzylpenicillin, which allows it to be given orally. It exerts a bactericidal action against penicillin-sensitive microorganisms during the stage of active multiplication. It acts by inhibiting the biosynthesis of cell-wall peptidoglycan. It is not active against beta-lactamase-producing bacteria, which include many strains of Staphylococci.[3]
Phenoxymethylpenicillin has a range of antimicrobial activity against Gram-positive bacteria that is similar to that of benzylpenicillin and a similar mode of action, but it is substantially less active than benzylpenicillin against Gram-negative bacteria.[1][2]
Category
Penicillinase-resistant penicillins
US Brand Names
PENICILLIN V POTASSIUM tablet®
FDA Package Insert
Description | Clinical Pharmacology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Dosage and Administration | How Supplied | Labels and Packages
Mechanism of Action
References
- ↑ 1.0 1.1 Garrod, L. P. (1960). "Relative Antibacterial Activity of Three Penicillins". British Medical Journal (5172): 527–29.
- ↑ 2.0 2.1 Garrod, L. P. (1960). "The Relative Antibacterial Activity of Four Penicillins". British Medical Journal (5214): 1695–6.
- ↑ "Penicillin V Potassium tablet: Drug Label Sections". U.S. National Library of Medicine, Daily Med: Current Medication Information. 12/2006. Retrieved 2009-08-02. Check date values in:
|date=(help)