Renal cell carcinoma other diagnostic studies: Difference between revisions
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==Histopathology== | ==Histopathology== | ||
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|+ '''''Histopathological Findings in Renal Cell Carcinoma<ref name="pmid19269025">{{cite journal| author=Rini BI, Campbell SC, Escudier B| title=Renal cell carcinoma. | journal=Lancet | year= 2009 | volume= 373 | issue= 9669 | pages= 1119-32 | pmid=19269025 | doi=10.1016/S0140-6736(09)60229-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19269025 }} </ref>''''' | |||
| bgcolor="#d9ff54"|'''Type''' || bgcolor="#d9ff54"|'''Characteristic Features''' | |||
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| bgcolor="#ececec"|'''Conventional (Clear Cell)''' ||*Nests of tumor cells that are compacted near each other<br>*Clear cytoplasm<br>*Delicate vasculature that separates the cytoplasm<br>*Varying architectural patterns, such as solid, alveolar, or acinar | |||
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| bgcolor="#ececec"|'''Papillary''' || *Papillae, tubulopapillae, and tubules that are present in differing percentages<br>*Type I generally has papillae lined with only 1 layer of cancer cells, pale cytoplasm, and small oval nuclei<br>*Type II generally are more heterogeneous tumors that have pseudostratification with large, spherical nuclei and distinct nucleoli | |||
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| bgcolor="#ececec"|'''Chromophobe''' || *Large polygonal cells<br>*Finely reticulated cytoplasm that may be eosinophilic<br>*Distinct cell borders<br>*Atypical nuclei with perinuclear halo | |||
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<sup><center>Adapted from Cohen HT, McGovern FJ. Renal-cell carcinoma.''N Engl J Med''. 2005; 353:2477-90 & Rini BI, Campbell SC, Escudier B. Renal cell carcinoma. ''Lancet'' 2009; 373(9669):1119-32</center></sup> | |||
==References== | ==References== | ||
Revision as of 16:12, 5 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Histopathology
| Type | Characteristic Features |
| Conventional (Clear Cell) | *Nests of tumor cells that are compacted near each other *Clear cytoplasm *Delicate vasculature that separates the cytoplasm *Varying architectural patterns, such as solid, alveolar, or acinar |
| Papillary | *Papillae, tubulopapillae, and tubules that are present in differing percentages *Type I generally has papillae lined with only 1 layer of cancer cells, pale cytoplasm, and small oval nuclei *Type II generally are more heterogeneous tumors that have pseudostratification with large, spherical nuclei and distinct nucleoli |
| Chromophobe | *Large polygonal cells *Finely reticulated cytoplasm that may be eosinophilic *Distinct cell borders *Atypical nuclei with perinuclear halo |
References
- ↑ Rini BI, Campbell SC, Escudier B (2009). "Renal cell carcinoma". Lancet. 373 (9669): 1119–32. doi:10.1016/S0140-6736(09)60229-4. PMID 19269025.