Cefazolin sodium: Difference between revisions
Gerald Chi (talk | contribs) |
Gerald Chi (talk | contribs) mNo edit summary |
||
| Line 33: | Line 33: | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
Cefazolin sodium belongs to the first-genaration [[Cephalosporins]].[[Cephalosporins]] are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as [[penicillins]]). [[Cephalosporins]] disrupt the synthesis of the [[peptidoglycan ]]layer of bacterial cell walls. The [[peptidoglycan ]]layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the [[peptidoglycan ]]is facilitated by transpeptidases known as [[ | Cefazolin sodium belongs to the first-genaration [[Cephalosporins]].[[Cephalosporins]] are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as [[penicillins]]). [[Cephalosporins]] disrupt the synthesis of the [[peptidoglycan]] layer of bacterial cell walls. The [[peptidoglycan]] layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the [[peptidoglycan]] is facilitated by transpeptidases known as [[penicillin-binding protein]]s (PBPs). | ||
==References== | ==References== | ||
Revision as of 00:25, 6 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]
Overview
Cefazolin (INN), also known as cefazoline or cephazolin, is a first generation cephalosporin antibiotic.
The drug is usually administrated either by intramuscular injection (injection into a large muscle) or intravenous infusion (intravenous fluid into a vein).
Category
Cephalosporin, First-Generation
US Brand Names
ANCEF®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Dosage and Administration | Compatibility, Reconstitution, and Stability | How Supplied | Labels and Packages
Mechanism of Action
Cefazolin sodium belongs to the first-genaration Cephalosporins.Cephalosporins are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin-binding proteins (PBPs).