Cefpodoxime: Difference between revisions

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{{drugbox |
__NOTOC__
| IUPAC_name = (6''R'',7''R'')-7-{[(2''Z'')-2-(2-amino-1,3-thiazol-4-yl)-<br>2-methoxyimino-acetyl]amino}-3-(methoxymethyl)-<br>8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-<br>carboxylic acid
| image = Cefpodoxime.svg
| width = 250
| CAS_number = 82619-04-3
| ATC_prefix = J01
| ATC_suffix = DD13
| PubChem = 6335986
| DrugBank =
| C = 15 | H = 17 | N = 5 | O = 6 | S = 2
| molecular_weight = 427.458 g/mol
| bioavailability = 50%
| protein_bound = 21% to 29%
| metabolism = Negligible. Cefpodoxime proxetil is metabolized to cefpodoxime by the [[liver]]
| elimination_half-life = 2 hours
| excretion = [[Kidney|Renal]], unchanged
| pregnancy_AU = B1
| pregnancy_US = B
| legal_AU =  <!-- Unscheduled / S2 / S3 / S4  / S8 -->
| legal_CA =  <!--                            / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK =  <!-- GSL        / P      / POM / CD / Class A, B, C -->
| legal_US = Rx-only
| routes_of_administration = Oral
}}
{{SI}}


{{Cefpodoxime}}


{{CMG}};{{AE}}{{AK}}
==Overview==
'''Cefpodoxime''' (marketed as the [[prodrug]] '''cefpodoxime proxetil''' by [[Pharmacia & Upjohn]] under the trade name '''Vantin&reg;''') is an oral third generation [[cephalosporin]] [[antibiotic]]. It is active against most [[Gram positive]] and [[Gram negative]] [[bacteria]]. Notable exceptions include ''[[Pseudomonas aeruginosa]]'', ''[[Enterococcus]]'', and ''[[Bacteroides|Bacteroides fragilis]]''. It is commonly used to treat acute [[otitis media]], [[pharyngitis]], and [[sinusitis]]. It also finds use as oral continuation therapy when [[intravenous]] cephalosporins (such as [[ceftriaxone]]) are no longer necessary for continued treatment. [[Pfizer]], the parent company of [[Pharmacia & Upjohn]], markets '''Cefpodoxime proxetil''' under the trade name '''Simplicef&reg;''' for veterinary use. The dose range in dogs is 5-10 mg/kg body weight, administered orally, once a day. Outside the US, Cefpodoxime proxetil is marketed as '''Banan&reg;.'''
'''Cefpodoxime''' (marketed as the [[prodrug]] '''cefpodoxime proxetil''' by [[Pharmacia & Upjohn]] under the trade name '''Vantin&reg;''') is an oral third generation [[cephalosporin]] [[antibiotic]]. It is active against most [[Gram positive]] and [[Gram negative]] [[bacteria]]. Notable exceptions include ''[[Pseudomonas aeruginosa]]'', ''[[Enterococcus]]'', and ''[[Bacteroides|Bacteroides fragilis]]''. It is commonly used to treat acute [[otitis media]], [[pharyngitis]], and [[sinusitis]]. It also finds use as oral continuation therapy when [[intravenous]] cephalosporins (such as [[ceftriaxone]]) are no longer necessary for continued treatment. [[Pfizer]], the parent company of [[Pharmacia & Upjohn]], markets '''Cefpodoxime proxetil''' under the trade name '''Simplicef&reg;''' for veterinary use. The dose range in dogs is 5-10 mg/kg body weight, administered orally, once a day. Outside the US, Cefpodoxime proxetil is marketed as '''Banan&reg;.'''


==Category==


[[Image:Cefpodoxime proxetil.svg|thumb|left|250px|[[Structural formula]] of cefpodoxime '''proxetil''']]
[[Cephalosporins]], third generation.
== External links ==
* {{PubChem|6526396}} - cefpodoxime proxetil
* [http://www.pfizer.com/pfizer/download/uspi_vantin.pdf  Vantin Tablets and Oral Suspension Full U.S. Prescribing Information] (from manufacturer's website)
* [http://www.simplicef.com/images/simplicef_pre_info.pdf Simplicef] (from manufacturer's website)


{{CephalosporinAntiBiotics}}
==US Brand Names==


[[Category:Cephalosporin antibiotics]]
VANTIN<sup>®</sup>
==FDA Package Insert==


[[th:เซฟโปดอกซิม]]
'''  [[Cefpodoxime description|Description]]'''
'''| [[Cefpodoxime clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Cefpodoxime microbiology|Microbiology]]'''
'''| [[Cefpodoxime indications and usage|Indications and Usage]]'''
'''| [[Cefpodoxime contraindications|Contraindications]]'''
'''| [[Cefpodoxime warnings|Warnings]]'''
'''| [[Cefpodoxime precautions|Precautions]]'''
'''| [[Cefpodoxime adverse reactions|Adverse Reactions]]'''
'''| [[Cefpodoxime overdosage|Overdosage]]'''
'''| [[Cefpodoxime clinical studies|Clinical Studies]]'''
'''| [[Cefpodoxime dosage and administration|Dosage and Administration]]'''
'''| [[Cefpodoxime compatibility reconstitution and stability|Compatibility, Reconstitution, and Stability]]'''
'''| [[Cefpodoxime directions for use|Directions For Use]]'''
'''| [[Cefpodoxime how supplied|How Supplied]]'''
'''| [[Cefpodoxime labels and packages|Labels and Packages]]'''




{{WH}}
==References==
{{WS}}
{{Reflist|2}}
http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/050674s015,050675s018lbl.pdf
[[Category:Antibiotics]]
[[Category:Wikinfect]]

Revision as of 15:32, 6 January 2014


Cefpodoxime Proxetil
VANTIN® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings
Precautions
Adverse Reactions
Overdosage
Clinical Studies
Dosage and Administration
How Supplied
Labels and Packages

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Abdurahman Khalil, M.D. [2]

Overview

Cefpodoxime (marketed as the prodrug cefpodoxime proxetil by Pharmacia & Upjohn under the trade name Vantin®) is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment. Pfizer, the parent company of Pharmacia & Upjohn, markets Cefpodoxime proxetil under the trade name Simplicef® for veterinary use. The dose range in dogs is 5-10 mg/kg body weight, administered orally, once a day. Outside the US, Cefpodoxime proxetil is marketed as Banan®.

Category

Cephalosporins, third generation.

US Brand Names

VANTIN®

FDA Package Insert

Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings | Precautions | Adverse Reactions | Overdosage | Clinical Studies | Dosage and Administration | Compatibility, Reconstitution, and Stability | Directions For Use | How Supplied | Labels and Packages


References

http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/050674s015,050675s018lbl.pdf

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