Neomycin drug interactions: Difference between revisions
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==Drug Interactions== | |||
Caution should be taken in concurrent or serial use of other neurotoxic and/or nephrotoxic drugs because of possible enhancement of the [[nephrotoxicity]] and/or [[ototoxicity]] of neomycin (see boxed WARNINGS ). | |||
Caution should also be taken in concurrent or serial use of other aminoglycosides and polymyxins because they may enhance neomycin's nephrotoxicity and/or ototoxicity and potentiate neomycin's neuromuscular blocking effects. | |||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = NEO-FRADIN (NEOMYCIN SULFATE) SOLUTION [X-GEN PHARMACEUTICALS, INC.] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=aea1d3e4-604a-4680-91e2-cce6a128a1b5 | publisher = | date = | accessdate = }}</ref> | Oral neomycin inhibits the gastrointestinal absorption of [[penicillin V]], oral vitamin B-12, [[methotrexate]] and [[5-fluorourcil]]. The gastrointestinal absorption of [[digoxin]] also appears to be inhibited. Therefore, digoxin serum levels should be monitored. | ||
Oral neomycin may enhance the effect of coumarin in anticoagulants by decreasing [[vitamin K]] availability.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = NEO-FRADIN (NEOMYCIN SULFATE) SOLUTION [X-GEN PHARMACEUTICALS, INC.] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=aea1d3e4-604a-4680-91e2-cce6a128a1b5 | publisher = | date = | accessdate = }}</ref> | |||
==References== | ==References== | ||
Revision as of 16:32, 6 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Drug Interactions
Caution should be taken in concurrent or serial use of other neurotoxic and/or nephrotoxic drugs because of possible enhancement of the nephrotoxicity and/or ototoxicity of neomycin (see boxed WARNINGS ).
Caution should also be taken in concurrent or serial use of other aminoglycosides and polymyxins because they may enhance neomycin's nephrotoxicity and/or ototoxicity and potentiate neomycin's neuromuscular blocking effects.
Oral neomycin inhibits the gastrointestinal absorption of penicillin V, oral vitamin B-12, methotrexate and 5-fluorourcil. The gastrointestinal absorption of digoxin also appears to be inhibited. Therefore, digoxin serum levels should be monitored.
Oral neomycin may enhance the effect of coumarin in anticoagulants by decreasing vitamin K availability.[1]
References
Adapted from the FDA Package Insert.