Artemether lumefantrine contraindications: Difference between revisions
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==Contraindications== | |||
===Hypersensitivity=== | |||
Known hypersensitivity to artemether, lumefantrine, or to any of the excipients of Coartem Tablets [see Adverse Reactions ]. | |||
===Strong CYP3A4 Inducers=== | |||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = COARTEM (ARTEMETHER AND LUMEFANTRINE) TABLET [NOVARTIS PHARMACEUTICALS CORPORATION] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7866ec19-dfac-47d4-a53f-511a12643cbf | publisher = | date = | accessdate }}</ref> | Co-administration of strong inducers of CYP3A4 such as rifampin, carbamazepine, phenytoin and St. John’s wort with Coartem Tablets can result in decreased concentrations of artemether and/or lumefantrine and loss of antimalarial efficacy [see Warnings and Precautions , Drug Interactions , and Clinical Pharmacology ].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = COARTEM (ARTEMETHER AND LUMEFANTRINE) TABLET [NOVARTIS PHARMACEUTICALS CORPORATION] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7866ec19-dfac-47d4-a53f-511a12643cbf | publisher = | date = | accessdate }}</ref> | ||
Revision as of 21:19, 6 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]
Contraindications
Hypersensitivity
Known hypersensitivity to artemether, lumefantrine, or to any of the excipients of Coartem Tablets [see Adverse Reactions ].
Strong CYP3A4 Inducers
Co-administration of strong inducers of CYP3A4 such as rifampin, carbamazepine, phenytoin and St. John’s wort with Coartem Tablets can result in decreased concentrations of artemether and/or lumefantrine and loss of antimalarial efficacy [see Warnings and Precautions , Drug Interactions , and Clinical Pharmacology ].[1]
References
- ↑ "COARTEM (ARTEMETHER AND LUMEFANTRINE) TABLET [NOVARTIS PHARMACEUTICALS CORPORATION]". Text " accessdate " ignored (help)
Adapted from the FDA Package Insert.