Albendazole drug interactions: Difference between revisions
Gerald Chi (talk | contribs) (Created page with "__NOTOC__ {{Albendazole}} {{CMG}} <ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = ALBENZA (ALBENDAZOLE) TABLET, FILM COATED [AMEDRA PHARMACEUT...") |
Gerald Chi (talk | contribs) mNo edit summary |
||
| Line 3: | Line 3: | ||
{{CMG}} | {{CMG}} | ||
==Drug Interactions== | |||
====Dexamethasone==== | |||
Steady-state trough concentrations of albendazole sulfoxide were about 56% higher when 8 mg dexamethasone was coadministered with each dose of albendazole (15 mg/kg/day) in 8 neurocysticercosis patients. | |||
====Praziquantel==== | |||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = ALBENZA (ALBENDAZOLE) TABLET, FILM COATED [AMEDRA PHARMACEUTICALS LLC] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e8941166-b77d-45aa-a6e8-04f1c0afd845 | publisher = | date = | accessdate = }}</ref> | In the fed state, praziquantel (40 mg/kg) increased mean maximum plasma concentration and area under the curve of albendazole sulfoxide by about 50% in healthy subjects (n = 10) compared with a separate group of subjects (n = 6) given albendazole alone. Mean Tmax and mean plasma elimination half-life of albendazole sulfoxide were unchanged. The pharmacokinetics of praziquantel were unchanged following coadministration with albendazole (400 mg). | ||
====Cimetidine==== | |||
Albendazole sulfoxide concentrations in bile and cystic fluid were increased (about 2-fold) in hydatid cyst patients treated with cimetidine (10 mg/kg/day) (n = 7) compared with albendazole (20 mg/kg/day) alone (n = 12). Albendazole sulfoxide plasma concentrations were unchanged 4 hours after dosing. | |||
====Theophylline==== | |||
The pharmacokinetics of theophylline (aminophylline 5.8 mg/kg infused over 20 minutes) were unchanged following a single oral dose of albendazole (400 mg) in 6 healthy subjects.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = ALBENZA (ALBENDAZOLE) TABLET, FILM COATED [AMEDRA PHARMACEUTICALS LLC] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e8941166-b77d-45aa-a6e8-04f1c0afd845 | publisher = | date = | accessdate = }}</ref> | |||
==References== | ==References== | ||
Latest revision as of 00:05, 7 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Drug Interactions
Dexamethasone
Steady-state trough concentrations of albendazole sulfoxide were about 56% higher when 8 mg dexamethasone was coadministered with each dose of albendazole (15 mg/kg/day) in 8 neurocysticercosis patients.
Praziquantel
In the fed state, praziquantel (40 mg/kg) increased mean maximum plasma concentration and area under the curve of albendazole sulfoxide by about 50% in healthy subjects (n = 10) compared with a separate group of subjects (n = 6) given albendazole alone. Mean Tmax and mean plasma elimination half-life of albendazole sulfoxide were unchanged. The pharmacokinetics of praziquantel were unchanged following coadministration with albendazole (400 mg).
Cimetidine
Albendazole sulfoxide concentrations in bile and cystic fluid were increased (about 2-fold) in hydatid cyst patients treated with cimetidine (10 mg/kg/day) (n = 7) compared with albendazole (20 mg/kg/day) alone (n = 12). Albendazole sulfoxide plasma concentrations were unchanged 4 hours after dosing.
Theophylline
The pharmacokinetics of theophylline (aminophylline 5.8 mg/kg infused over 20 minutes) were unchanged following a single oral dose of albendazole (400 mg) in 6 healthy subjects.[1]
References
Adapted from the FDA Package Insert.