Bithionol: Difference between revisions
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====Dosage==== | ====Dosage==== | ||
======Normal Dosage====== | ======Adult Normal Dosage====== | ||
'''Oral route''' | '''Oral route''' | ||
1) The recommended oral dose of bithionol for the treatment of Fascioliasis, and as alternative therapy in Paragonimiasis, is 30 to 50 milligrams/kilogram on alternate days for 10 to 15 doses. | 1) The recommended oral dose of bithionol for the treatment of Fascioliasis, and as alternative therapy in Paragonimiasis, is 30 to 50 milligrams/kilogram on alternate days for 10 to 15 doses. | ||
2) Bithionol is usually given in 2 or 3 divided doses, and after meals to minimize gastrointestinal symptoms. | 2) Bithionol is usually given in 2 or 3 divided doses, and after meals to minimize gastrointestinal symptoms. | ||
======Pediatric Normal Dosage====== | |||
'''Oral route''' | |||
1) The recommended pediatric oral dose of bithionol for the treatment of Fascioliasis, and as alternative therapy in Paragonimiasis, is 30 to 50 milligrams/kilogram on alternate days for 10 to 15 doses. | |||
2) Bithionol is usually given in 2 or 3 divided doses, and after meals to minimize gastrointestinal symptoms. | |||
====Pharmacokinetics==== | |||
'''Onset''' | |||
* Initial Response | |||
a) Fascioliasis, 2 to 9 days. | |||
b) Resolution of fever has been reported 2 days after initiation of BITHIONOL therapy in fascioliasis, with eradication of ova in stools after 9 days. | |||
c) Paragonimiasis, 3 to 5 days. (Significant improvement of hemoptysis in paragonimiasis has been reported after the third dose of oral BITHIONOL. Eradication of Paragonimus westermani ova has occurred after the fifth dose.) | |||
==Mechanism of Action== | ==Mechanism of Action== | ||
Revision as of 01:43, 7 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Overview
Bithionol is an anthelmintic used to treat "Anoplocephala perfoliata" (tapeworms) in horses[1] and Fasciola hepatica (liver flukes).
Category
Antiparasite
Brand Names
Bithionol is investigational in the U.S. The drug can be obtained from the Centers for Disease Control (CDC) Drug Service, CDC, Atlanta, Georgia 30333 (404-639-3670; evenings, weekends, or holidays: 404-639-2888).
Prescribing Information
Dosage
Adult Normal Dosage
Oral route 1) The recommended oral dose of bithionol for the treatment of Fascioliasis, and as alternative therapy in Paragonimiasis, is 30 to 50 milligrams/kilogram on alternate days for 10 to 15 doses.
2) Bithionol is usually given in 2 or 3 divided doses, and after meals to minimize gastrointestinal symptoms.
Pediatric Normal Dosage
Oral route 1) The recommended pediatric oral dose of bithionol for the treatment of Fascioliasis, and as alternative therapy in Paragonimiasis, is 30 to 50 milligrams/kilogram on alternate days for 10 to 15 doses.
2) Bithionol is usually given in 2 or 3 divided doses, and after meals to minimize gastrointestinal symptoms.
Pharmacokinetics
Onset
- Initial Response
a) Fascioliasis, 2 to 9 days. b) Resolution of fever has been reported 2 days after initiation of BITHIONOL therapy in fascioliasis, with eradication of ova in stools after 9 days. c) Paragonimiasis, 3 to 5 days. (Significant improvement of hemoptysis in paragonimiasis has been reported after the third dose of oral BITHIONOL. Eradication of Paragonimus westermani ova has occurred after the fifth dose.)