Halofantrine: Difference between revisions

Revision as of 02:42, 7 January 2014

Halofantrine
HALFAN^® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Dosage and Administration
How Supplied

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Halofantrine is a drug used to treat malaria. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It is never used to prevent malaria. Its mode of action is unknown.

US Brand Names

HALFAN

FDA Package Insert

Mechanism of Action

The mechanism of action of halofantrine is unknown. The absorption of halofantrine is erratic, but is increased when taken with fatty food. Because of fears of toxicity due to increased halofantrine blood levels, halofantrine should be taken on an empty stomach.

Plasma levels peak at 16 hours and the half-life of the drug is about 4 days.

Adverse reactions

Halofantrine can cause abdominal pain, diarrhoea, vomiting, rash, headache, itching and elevated liver enzymes. The most dangerous side effect is cardiac arrhythmias: halofantrine causes significant QT prolongation, and this effect is seen even at standard doses. The drug should therefore not be given to patients with cardiac conduction defects and should not be combined with mefloquine.

Pharmacology

References

@@ Line 1: / Line 1: @@
-{{drugbox
+__NOTOC__
-|IUPAC_name=3-dibutylamino-1-[1,3-dichloro-6-(trifluoromethyl)<br>phenanthren-9-yl]-propan-1-ol
+{{Halofantrine}}
-|image=Halofantrine.svg
+{{CMG}}
-|CAS_number=69756-53-2
-|ATC_prefix=P01
-|ATC_suffix=BX01
-|ATC_supplemental=
-|PubChem=37393
-|DrugBank=APRD00419
-|C=26|H=30|Cl=2|F=3|N=1|O=1
-|molecular_weight=500.423 g/mol
-|bioavailability=
-|protein_bound=60 to 70%
-|metabolism=[[Liver|Hepatic]] ([[CYP3A4]]-mediated)
-|elimination_half-life=6 to 10 days
-|excretion=
-|pregnancy_AU=<!-- A / B1 / B2 / B3 / C / D / X -->
-|pregnancy_US=<!-- A / B / C / D / X -->
-|pregnancy_category=
-|legal_AU=<!-- Unscheduled / S2 / S4 / S8 -->
-|legal_UK=<!-- GSL / P / POM / CD -->
-|legal_US=<!-- OTC / Rx-only -->
-|legal_status=
-|routes_of_administration=Oral
-}}
-'''Halofantrine''' is a drug used to treat [[malaria]].  It belongs to the [[phenanthrene]] class of compounds that includes [[quinine]] and [[lumefantrine]].  It is never used to prevent malaria.  Its mode of action is unknown.
-==Adverse reactions==
+==Overview==
-Halofantrine can cause abdominal pain, [[diarrhoea]], vomiting, rash, headache, itching and elevated liver enzymes.  The most dangerous side effect is [[cardiac arrhythmia]]s: halofantrine causes significant [[QT prolongation]], and this effect is seen even at standard doses.  The drug should therefore not be given to patients with cardiac conduction defects and should not be combined with [[mefloquine]].
+Halofantrine is a drug used to treat [[malaria]].  It belongs to the [[phenanthrene]] class of compounds that includes [[quinine]] and [[lumefantrine]].  It is never used to prevent malaria.  Its mode of action is unknown.
+==Category==
+==US Brand Names==
+HALFAN
+==FDA Package Insert==
+'''  [[XXXXX description|Description]]'''
+'''| [[XXXXX clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[XXXXX microbiology|Microbiology]]'''
+'''| [[XXXXX indications and usage|Indications and Usage]]'''
+'''| [[XXXXX contraindications|Contraindications]]'''
+'''| [[XXXXX warnings and precautions|Warnings and Precautions]]'''
+'''| [[XXXXX adverse reactions|Adverse Reactions]]'''
+'''| [[XXXXX drug interactions|Drug Interactions]]'''
+'''| [[XXXXX overdosage|Overdosage]]'''
+'''| [[XXXXX clinical studies|Clinical Studies]]'''
+'''| [[XXXXX dosage and administration|Dosage and Administration]]'''
+'''| [[XXXXX how supplied|How Supplied]]'''
+'''| [[XXXXX labels and packages|Labels and Packages]]'''
-==Pharmacology==
+==Mechanism of Action==
 The mechanism of action of halofantrine is unknown.  The absorption of halofantrine is erratic, but is increased when taken with fatty food.  Because of fears of toxicity due to increased halofantrine blood levels, halofantrine should be taken on an empty stomach.
 Plasma levels peak at 16 hours and the half-life of the drug is about 4 days.
-==Uses==
-Halofantrine is only used to treat malaria.  It is not used to prevent malaria ([[prophylaxis]]) because of the risk of toxicity and unreliable absorption.
-==Dosing==
-*Adult dose: Three doses of 500&nbsp;mg six hours apart.
-Halofantrine should be taken on an empty stomach.
+==Adverse reactions==
+Halofantrine can cause abdominal pain, [[diarrhoea]], vomiting, rash, headache, itching and elevated liver enzymes.  The most dangerous side effect is [[cardiac arrhythmia]]s: halofantrine causes significant [[QT prolongation]], and this effect is seen even at standard doses.  The drug should therefore not be given to patients with cardiac conduction defects and should not be combined with [[mefloquine]].
+==Pharmacology==
-==Manufacturing information and availability==
-*'''Halfan''' ([[GlaxoSmithKline]]) is available as 250&nbsp;mg tablets.  A full treatment cost (6 tablets) costs [[United States dollar|US$]]1.40 in the developing world.  Halofantrine is not available in the UK or U.S.
 ==References==
-* {{cite book |last=Rosenthal |first=Philip J. |editor=Katzung BG. |title=Basic &amp; Clinical Pharmacology |origdate= |origyear= |origmonth= |url= |format= |accessdate= |accessyear= |accessmonth= |edition=9 |date= |year=2004 |publisher=Lange Medical Books |location=New York |isbn=0-07-141092-9 |pages=874&ndash;5 |chapter=Antiprotozoal drugs }}
+{{Reflist|2}}
-{{Antimalarials}}
-{{antimicrobial-stub}}
+[[Category:Antibiotics]]
-[[Category:Antimalarial agents]]
+[[Category:Wikinfect]]
-{{WikiDoc Sources}}