Tinidazole warnings and precautions: Difference between revisions
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Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, have been reported in patients treated with tinidazole. The appearance of abnormal neurologic signs demands the prompt discontinuation of tinidazole therapy. | Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, have been reported in patients treated with tinidazole. The appearance of abnormal neurologic signs demands the prompt discontinuation of tinidazole therapy. | ||
===Vaginal Candidiasis=== | ===[[Vaginal Candidiasis]]=== | ||
The use of tinidazole may result in Candida vaginitis. In a clinical study of 235 women who received tinidazole for bacterial vaginosis, a vaginal fungal infection developed in 11 (4.7%) of all study subjects [see Clinical Studies (14.5)]. | The use of tinidazole may result in Candida vaginitis. In a clinical study of 235 women who received tinidazole for bacterial vaginosis, a vaginal fungal infection developed in 11 (4.7%) of all study subjects [see Clinical Studies (14.5)]. | ||
=== | ===[[Blood Dyscrasia]]=== | ||
Tinidazole should be used with caution in patients with evidence of or history of blood dyscrasia [see Drug Interactions (7.3)]. | Tinidazole should be used with caution in patients with evidence of or history of blood dyscrasia [see Drug Interactions (7.3)]. | ||
Latest revision as of 20:03, 7 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]
Warnings and Precautions
Neurological Adverse Reactions
Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, have been reported in patients treated with tinidazole. The appearance of abnormal neurologic signs demands the prompt discontinuation of tinidazole therapy.
Vaginal Candidiasis
The use of tinidazole may result in Candida vaginitis. In a clinical study of 235 women who received tinidazole for bacterial vaginosis, a vaginal fungal infection developed in 11 (4.7%) of all study subjects [see Clinical Studies (14.5)].
Blood Dyscrasia
Tinidazole should be used with caution in patients with evidence of or history of blood dyscrasia [see Drug Interactions (7.3)].
Drug Resistance
Prescribing Tindamax in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.[1]
References
Adapted from the FDA Package Insert.