Hydroxychloroquine sulfate Dosage And Administration: Difference between revisions
(Created page with "__NOTOC__ {{Hydroxychloroquine sulfate}} {{CMG}}; {{AE}} {{chetan}} <ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = HYDROXYCHLOROQUINE SULFATE (...") |
No edit summary |
||
| Line 3: | Line 3: | ||
{{CMG}}; {{AE}} {{chetan}} | {{CMG}}; {{AE}} {{chetan}} | ||
==Dosage And Administration== | |||
One tablet of 200 mg of hydroxychloroquine sulfate, USP is equivalent to 155 mg base. | |||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = HYDROXYCHLOROQUINE SULFATE (HYDROXYCHLOROQUINE SULFATE) TABLET, FILM COATED [IPCA LABORATORIES LIMITED] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=22d4d993-b86d-478e-ac6d-7bcd217e9906 | publisher = | date = | accessdate = }}</ref> | ===Malaria Suppression=== | ||
In adults, 400 mg (=310 mg base) on exactly the same day of each week. In infants and children, the weekly suppressive dosage is 5 mg, calculated as base, per kg of body weight, but should not exceed the adult dose regardless of weight. | |||
If circumstances permit, suppressive therapy should begin two weeks prior to exposure. However, failing this, in adults an initial double (loading) dose of 800 mg (=620 mg base), or in children 10 mg base/kg may be taken in two divided doses, six hours apart. The suppressive therapy should be continued for eight weeks after leaving the endemic area. | |||
===Treatment of the acute attack=== | |||
In adults, an initial dose of 800 mg (=620 mg base) followed by 400 mg (=310 mg base) in six to eight hours and 400 mg (=310 mg base) on each of two consecutive days (total 2 g hydroxychloroquine sulfate, USP or 1.55 g base). An alternative method, employing a single dose of 800 mg (=620 mg base), has also proved effective. | |||
The dosage for adults may also be calculated on the basis of body weight; this method is preferred for infants and children. A total dose representing 25 mg of base per kg of body weight is administered in three days, as follows: | |||
*First dose: 10 mg base per kg (but not exceeding a single dose of 620 mg base). | |||
*Second dose: 5 mg base per kg (but not exceeding a single dose of 310 mg base) 6 hours after first dose. | |||
*Third dose: 5 mg base per kg 18 hours after second dose. | |||
*Fourth dose: 5 mg base per kg 24 hours after third dose. | |||
For radical cure of vivax and malariae malaria concomitant therapy with an 8-aminoquinoline compound is necessary. <ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = HYDROXYCHLOROQUINE SULFATE (HYDROXYCHLOROQUINE SULFATE) TABLET, FILM COATED [IPCA LABORATORIES LIMITED] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=22d4d993-b86d-478e-ac6d-7bcd217e9906 | publisher = | date = | accessdate = }}</ref> | |||
==References== | ==References== | ||
Latest revision as of 00:09, 8 January 2014
| Hydroxychloroquine sulfate |
|---|
| HYDROXYCHLOROQUINE SULFATE® FDA Package Insert |
| Description |
| Clinical Pharmacology |
| Microbiology |
| Indications And Usage |
| Contraindications |
| Warnings And Precautions |
| Adverse Reactions |
| Overdosage |
| Dosage And Administration |
| How Supplied |
| Labels And Packages |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]
Dosage And Administration
One tablet of 200 mg of hydroxychloroquine sulfate, USP is equivalent to 155 mg base.
Malaria Suppression
In adults, 400 mg (=310 mg base) on exactly the same day of each week. In infants and children, the weekly suppressive dosage is 5 mg, calculated as base, per kg of body weight, but should not exceed the adult dose regardless of weight.
If circumstances permit, suppressive therapy should begin two weeks prior to exposure. However, failing this, in adults an initial double (loading) dose of 800 mg (=620 mg base), or in children 10 mg base/kg may be taken in two divided doses, six hours apart. The suppressive therapy should be continued for eight weeks after leaving the endemic area.
Treatment of the acute attack
In adults, an initial dose of 800 mg (=620 mg base) followed by 400 mg (=310 mg base) in six to eight hours and 400 mg (=310 mg base) on each of two consecutive days (total 2 g hydroxychloroquine sulfate, USP or 1.55 g base). An alternative method, employing a single dose of 800 mg (=620 mg base), has also proved effective.
The dosage for adults may also be calculated on the basis of body weight; this method is preferred for infants and children. A total dose representing 25 mg of base per kg of body weight is administered in three days, as follows:
- First dose: 10 mg base per kg (but not exceeding a single dose of 620 mg base).
- Second dose: 5 mg base per kg (but not exceeding a single dose of 310 mg base) 6 hours after first dose.
- Third dose: 5 mg base per kg 18 hours after second dose.
- Fourth dose: 5 mg base per kg 24 hours after third dose.
For radical cure of vivax and malariae malaria concomitant therapy with an 8-aminoquinoline compound is necessary. [1]
References
Adapted from the FDA Package Insert.