Sulfanilamide: Difference between revisions
| Line 5: | Line 5: | ||
{{CMG}}; {{AE}} {{MM}} | {{CMG}}; {{AE}} {{MM}} | ||
==Overview== | ==Overview== | ||
'''Sulfanilamide''' (also spelled '''sulphanilamide''') is a [[sulfonamide (medicine)|sulfonamide]] [[antibacterial]]. Chemically, it is a molecule containing the [[Sulfonamide (chemistry)|sulfonamide]] functional group attached to an [[aniline]]. | |||
Sulfanilamide was first prepared in 1908 by Paul Gelmo as part of his dissertation for a doctoral degree from the Technische Hochsschule of Vienna, Austria.<ref>Paul Gelmo (May 14, 1908) [http://gallica.bnf.fr/ark:/12148/bpt6k90849c/f378.image "Über Sulfamide der p-Amidobenzolsulfonsäure,"] ''Journal für Praktische Chemie'', '''77''' : 369-382.</ref> It was patented in 1909.<ref>On May 18, 1909, Deutsches Reich Patentschrift number 226,239 for sulfanilamide was awarded to Heinrich Hörlein of the Bayer corporation.</ref> | |||
==Category== | ==Category== | ||
Revision as of 08:36, 9 January 2014
For patient information, click here.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]
Overview
Sulfanilamide (also spelled sulphanilamide) is a sulfonamide antibacterial. Chemically, it is a molecule containing the sulfonamide functional group attached to an aniline.
Sulfanilamide was first prepared in 1908 by Paul Gelmo as part of his dissertation for a doctoral degree from the Technische Hochsschule of Vienna, Austria.[1] It was patented in 1909.[2]
Category
US Brand Names
AVC VAGINAL®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Overdosage | Dosage and Administration | How Supplied | Labels and Packages
Mechanism of Action
As a sulfonamide antibiotic, it functions by competitively inhibiting (i.e., by acting as a substrate analogue) enzymatic reactions involving para-aminobenzoic acid (PABA).[3] PABA is needed in enzymatic reactions that produce folic acid which acts as a coenzyme in the synthesis of purine, pyrimidine and other amino acids.
References
- ↑ Paul Gelmo (May 14, 1908) "Über Sulfamide der p-Amidobenzolsulfonsäure," Journal für Praktische Chemie, 77 : 369-382.
- ↑ On May 18, 1909, Deutsches Reich Patentschrift number 226,239 for sulfanilamide was awarded to Heinrich Hörlein of the Bayer corporation.
- ↑ Michael Kent, Advanced Biology, Oxford University Press, 2000, p. 46 ISBN 978-0-19-914195-1