Amphotericin B lipid complex overdosage: Difference between revisions

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Amphotericin B desoxycholate overdose has been reported to result in cardio-respiratory arrest. Fifteen patients have been reported to have received one or more doses of ABELCET® between 7-13 mg/kg. None of these patients had a serious acute reaction to ABELCET®.  
Amphotericin B desoxycholate overdose has been reported to result in cardio-respiratory arrest. Fifteen patients have been reported to have received one or more doses of ABELCET® between 7-13 mg/kg. None of these patients had a serious acute reaction to ABELCET®.  


If an overdose is suspected, '''discontinue''' therapy, '''monitor''' the patient’s clinical status, and '''administer''' supportive therapy as required. ABELCET® is '''not hemodialyzable'''.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = ABELCET (AMPHOTERICIN B, DIMYRISTOYLPHOSPHATIDYLCHOLINE, DL- AND DIMYRISTOYLPHOSPHATIDYLGLYCEROL, DL-) INJECTION [SIGMA-TAU PHARMACEUTICALS, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5587db37-f21a-4a39-a319-e1077032ced9 | publisher =  | date =  | accessdate =  }}</ref>
If an overdose is suspected:
#'''Discontinue''' therapy
#'''Monitor''' the patient’s clinical status
#'''Administer''' supportive therapy as required. ABELCET® is '''not hemodialyzable'''.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = ABELCET (AMPHOTERICIN B, DIMYRISTOYLPHOSPHATIDYLCHOLINE, DL- AND DIMYRISTOYLPHOSPHATIDYLGLYCEROL, DL-) INJECTION [SIGMA-TAU PHARMACEUTICALS, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5587db37-f21a-4a39-a319-e1077032ced9 | publisher =  | date =  | accessdate =  }}</ref>


==References==
==References==

Revision as of 06:13, 10 January 2014

Amphotericin B lipid complex
ABELCET® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Dosage and Administration
How Supplied
Labels and Packages

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]

Overdosage

Amphotericin B desoxycholate overdose has been reported to result in cardio-respiratory arrest. Fifteen patients have been reported to have received one or more doses of ABELCET® between 7-13 mg/kg. None of these patients had a serious acute reaction to ABELCET®.

If an overdose is suspected:

  1. Discontinue therapy
  2. Monitor the patient’s clinical status
  3. Administer supportive therapy as required. ABELCET® is not hemodialyzable.[1]

References

  1. "ABELCET (AMPHOTERICIN B, DIMYRISTOYLPHOSPHATIDYLCHOLINE, DL- AND DIMYRISTOYLPHOSPHATIDYLGLYCEROL, DL-) INJECTION [SIGMA-TAU PHARMACEUTICALS, INC.]".

Adapted from the FDA Package Insert.