Renal cell carcinoma causes: Difference between revisions
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{{Renal cell carcinoma}} | {{Renal cell carcinoma}} | ||
==Overview== | ==Overview== | ||
Most renal cell carcinomas develop sporadically. Only a few have genetic predisposition and are associated with known syndromes, such as von Hippel Lindau (VHL), hereditary paragangliomas, leiomyomatosis, and | Most renal cell carcinomas develop sporadically. Only a few have genetic predisposition and are associated with known syndromes, such as von Hippel Lindau (VHL), hereditary paragangliomas, leiomyomatosis, and Birt-Hogg-Dube (BHD) syndrome, among several others. | ||
==Causes== | ==Causes== | ||
Sporadic development of renal cell carcinomas contributes to the majority of cases of the most common renal cell carcinoma, the conventional (or clear cell) carcinoma. | Sporadic development of renal cell carcinomas contributes to the majority of cases of the most common renal cell carcinoma, the conventional (or clear cell) carcinoma. | ||
Revision as of 19:09, 12 January 2014
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Overview
Most renal cell carcinomas develop sporadically. Only a few have genetic predisposition and are associated with known syndromes, such as von Hippel Lindau (VHL), hereditary paragangliomas, leiomyomatosis, and Birt-Hogg-Dube (BHD) syndrome, among several others.
Causes
Sporadic development of renal cell carcinomas contributes to the majority of cases of the most common renal cell carcinoma, the conventional (or clear cell) carcinoma.
The following tables show the sporadic and hereditary renal-cell carcinomas and associated causes:
Sporadic Forms of Renal Cell Carcinoma
| Histologic Appearance | Incidence | Gene | Frequency |
| Conventional (Clear Cell) | 75 | VHL | 60 % |
| Papillary | 12 | MET TFE3 |
13 % < 1 % |
| Chromophobe | 4 | ||
| Oncocytoma | 4 | ||
| Collecting Duct | < 1 | ||
| Unclassified | 3 - 5 |
Hereditary Forms of Renal Cell Carcinoma
| Syndrome | Associated Gene | Common Histological Appearance |
| VHL Disease | VHL | Conventional (Clear Cell) |
| FCRC | Chromosome 3p translocation | Conventional (Clear Cell) |
| Hereditary Paraganglioma | SDHB | Conventional (Clear Cell) |
| HPRC | MET | Papillary |
| HLRCC | FH | Papillary |
| Birt-Hogg-Dube Syndrome | BHD | Chromophobe / Oncocytoma |
References
- ↑ 1.0 1.1 Cohen HT, McGovern FJ (2005). "Renal-cell carcinoma". N Engl J Med. 353 (23): 2477–90. doi:10.1056/NEJMra043172. PMID 16339096.