Glycoprotein IIb/IIIa: Difference between revisions
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==Overview== | ==Overview== | ||
In [[medicine]], '''glycoprotein IIb/IIIa''' | In [[medicine]], '''glycoprotein IIb/IIIa''' ('''gpIIb/IIIa''', also known as '''integrin α<sub>IIb</sub>β<sub>3</sub>''') is an [[integrin]] complex found on [[platelet]]s. It is a receptor for [[fibrinogen]]<ref name="Vickers_1999"/> and aids in [[coagulation#Platelet activation|platelet activation]]. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and endothelial adherence.<ref name="pmid7535429">{{cite journal | author = Calvete JJ | title = On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor | journal = Proc. Soc. Exp. Biol. Med. | volume = 208 | issue = 4 | pages = 346–60 | year = 1995 | pmid = 7535429 | doi = | issn = }}</ref><ref name="pmid10605720">{{cite journal | author = Shattil SJ | title = Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways | journal = Thromb. Haemost. | volume = 82 | issue = 2 | pages = 318–25 | year = 1999 | pmid = 10605720 | doi = | issn = }}</ref> Platelet activation by [[Adenosine diphosphate|ADP]] (blocked by [[clopidogrel]]) leads to a conformational change in platelet gpIIb/IIIa receptors that induces binding to fibrin.<ref name="Vickers_1999">{{cite journal | author = Vickers JD | title = Binding of polymerizing fibrin to integrin alpha(IIb)beta(3) on chymotrypsin-treated rabbit platelets decreases phosphatidylinositol 4,5-bisphosphate and increases cytoskeletal actin | journal = Platelets | volume = 10 | issue = 4 | pages = 228–37 |date=July 1999 | pmid = 16801097 | doi = 10.1080/09537109976077 }}</ref> The gpIIb/IIIa receptor is a target of several drugs including [[abciximab]], [[eptifibatide]], [[tirofiban]]. | ||
==Pathology== | ==Pathology== | ||
Defects in glycoprotein IIb/IIIa cause [[Glanzmann's thrombasthenia]].<ref name="pmid12163005">{{cite journal | author = Bellucci S, Caen J | title = Molecular basis of Glanzmann's Thrombasthenia and current strategies in treatment | journal = Blood Rev. | volume = 16 | issue = 3 | pages = 193–202 | year = 2002 | pmid = 12163005 | doi = 10.1016/S0268-960X(02)00030-9 }}</ref> | |||
Autoantibodies against IIb/IIIa can be produced in [[immune thrombocytopenic purpura]].<ref name="pmid18096470">{{cite journal | author = McMillan R | title = The pathogenesis of chronic immune thrombocytopenic purpura | journal = Semin. Hematol. | volume = 44 | issue = 4 Suppl 5 | pages = S3–S11 |date=October 2007 | pmid = 18096470 | doi = 10.1053/j.seminhematol.2007.11.002 }}</ref> | |||
==Medicine== | |||
[[Glycoprotein IIb/IIIa inhibitors]] can be used to prevent blood clots in an effort to decrease the risk of [[heart attack]] or [[stroke]]. | |||
==See also== | ==See also== | ||
*[[Glycoprotein IIb/IIIa inhibitors]] | *[[Glycoprotein IIb/IIIa inhibitors]] | ||
==References== | |||
{{Reflist|2}} | |||
==External links== | ==External links== | ||
Revision as of 15:56, 30 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
In medicine, glycoprotein IIb/IIIa (gpIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a receptor for fibrinogen[1] and aids in platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and endothelial adherence.[2][3] Platelet activation by ADP (blocked by clopidogrel) leads to a conformational change in platelet gpIIb/IIIa receptors that induces binding to fibrin.[1] The gpIIb/IIIa receptor is a target of several drugs including abciximab, eptifibatide, tirofiban.
Pathology
Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia.[4]
Autoantibodies against IIb/IIIa can be produced in immune thrombocytopenic purpura.[5]
Medicine
Glycoprotein IIb/IIIa inhibitors can be used to prevent blood clots in an effort to decrease the risk of heart attack or stroke.
See also
References
- ↑ 1.0 1.1 Vickers JD (July 1999). "Binding of polymerizing fibrin to integrin alpha(IIb)beta(3) on chymotrypsin-treated rabbit platelets decreases phosphatidylinositol 4,5-bisphosphate and increases cytoskeletal actin". Platelets. 10 (4): 228–37. doi:10.1080/09537109976077. PMID 16801097.
- ↑ Calvete JJ (1995). "On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor". Proc. Soc. Exp. Biol. Med. 208 (4): 346–60. PMID 7535429.
- ↑ Shattil SJ (1999). "Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways". Thromb. Haemost. 82 (2): 318–25. PMID 10605720.
- ↑ Bellucci S, Caen J (2002). "Molecular basis of Glanzmann's Thrombasthenia and current strategies in treatment". Blood Rev. 16 (3): 193–202. doi:10.1016/S0268-960X(02)00030-9. PMID 12163005.
- ↑ McMillan R (October 2007). "The pathogenesis of chronic immune thrombocytopenic purpura". Semin. Hematol. 44 (4 Suppl 5): S3–S11. doi:10.1053/j.seminhematol.2007.11.002. PMID 18096470.
External links
- Glycoproteins+IIb-IIIa at the US National Library of Medicine Medical Subject Headings (MeSH)