Abciximab contraindications

Template:Abciximab Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2], Pratik Bahekar, MBBS [3]

Contraindications

Because Abciximab may increase the risk of bleeding, Abciximab is contraindicated in the following clinical situations:

• Active internal bleeding
• Recent (within six weeks) gastrointestinal (GI) or genitourinary (GU) bleeding of clinical significance.
• History of cerebrovascular accident (CVA) within two years, or CVA with a significant residual neurological deficit
• Bleeding diathesis
• Administration of oral anticoagulants within seven days unless prothrombin time is <1.2 times control
• Thrombocytopenia (<100,000 cells/mL)
• Recent (within six weeks) major surgery or trauma
• Intracranial neoplasm, arteriovenous malformation, or aneurysm
• Severe uncontrolled hypertension
• Presumed or documented history of vasculitis
• Use of intravenous dextran before PCI, or intent to use it during an intervention

Abciximab is also contraindicated in patients with known hypersensitivity to any component of this product or to murine proteins.

References

Adapted from the FDA Package Insert.