Amyl nitrite warnings and precautions: Difference between revisions

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==Precautions==
==Precautions==


Amyl nitrite is very flammable.  Do not use where it might become ignited.  General - Tolerance to amyl nitrite may develop with repeated use of the drug for prolonged periods of time.  Tolerance may be minimized by beginning with the smallest effective dose and alternating the drug with another coronary [[vasodilator]].  High doses of nitrites may produce [[methemoglobinemia]], especially in individuals with methemoglobin reductase deficiency or other metabolic abnormality that interferes with the normal conversion of methemoglobin back to hemoglobin.
Amyl nitrite is very flammable.  Do not use where it might become ignited.  General - Tolerance to amyl nitrite may develop with repeated use of the drug for prolonged periods of time.  Tolerance may be minimized by beginning with the smallest effective dose and alternating the drug with another coronary [[vasodilator]].  High doses of nitrites may produce [[methemoglobinemia]], especially in individuals with methemoglobin reductase deficiency or other metabolic abnormality that interferes with the normal conversion of methemoglobin back to hemoglobin.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = AMYL NITRITE INHALANT [JAMES ALEXANDER CORPORATION] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c1b6e536-df5f-4f76-8e3c-6dc2f1e9975e | publisher =  | date =  | accessdate = 30 January 2014 }}</ref>
 
===Carcinogenesis, Mutagenesis, Fertility Impairment===
 
Adequate long term studies to establish adverse carcinogenic potential of this drug have not been reported.
 
===Pregnancy===
 
Teratogenic effects. Category C.  Animal studies have not been conducted with amyl nitrite.  It is also not known whether amyl nitrite can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Amyl nitrite should be given to a pregnant woman only if clearly needed.
 
===Nursing Mothers===
 
It is not known whether this drug is excreted in human milk.  Because many drugs are excreted in human milk, caution should be exercised when amyl nitrite is administered to a nursing woman.
 
===Pediatric Use===
 
Safety and effectiveness in children have not been established.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = AMYL NITRITE INHALANT [JAMES ALEXANDER CORPORATION] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c1b6e536-df5f-4f76-8e3c-6dc2f1e9975e | publisher =  | date =  | accessdate = 30 January 2014 }}</ref>


==References==
==References==

Revision as of 23:36, 30 January 2014

Amyl nitrite
Amyl nitrite tablet® FDA Package Insert
Indications and Usage
Dosage and Administration
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Description
Clinical Pharmacology
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
Clinical Trials
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]


Warnings

Transient episodes of dizziness, weakness, or syncope or other signs of cerebral ischemia due to postural hypotension may develop following inhalation of amyl nitrite, particularly if the patient is standing immobile. To hasten recovery, measures which facilitate venous return such as head low posture, deep breathing and movement of extremities may be used.


Precautions

Amyl nitrite is very flammable. Do not use where it might become ignited. General - Tolerance to amyl nitrite may develop with repeated use of the drug for prolonged periods of time. Tolerance may be minimized by beginning with the smallest effective dose and alternating the drug with another coronary vasodilator. High doses of nitrites may produce methemoglobinemia, especially in individuals with methemoglobin reductase deficiency or other metabolic abnormality that interferes with the normal conversion of methemoglobin back to hemoglobin.[1]

References

  1. ↑ "AMYL NITRITE INHALANT [JAMES ALEXANDER CORPORATION]". Retrieved 30 January 2014.
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