Amyl nitrite overdosage: Difference between revisions
No edit summary |
No edit summary |
||
| Line 7: | Line 7: | ||
===Symptons=== | ===Symptons=== | ||
Inhaled doses of 5 to 10 drops of amyl nitrite may cause violent flushing of the face, accompanied by a feeling of imminent bursting of the head and very excessive heart action. The inhalation of larger amounts may produce a feeling of suffocation and muscular weakness. Symptons comparable to shock may be produced such as weakness, restlessness, sweating pallor, nausea, vomiting, [[ | Inhaled doses of 5 to 10 drops of amyl nitrite may cause violent flushing of the face, accompanied by a feeling of imminent bursting of the head and very excessive heart action. The inhalation of larger amounts may produce a feeling of suffocation and muscular weakness. Symptons comparable to shock may be produced such as weakness, restlessness, sweating, [[pallor]], [[nausea]], [[vomiting]], [[syncope]] and [[incontinence]] attributable to pooling of blood in the postarteriolar vessels and failure of the venous blood to return to the heart. | ||
===Treatment=== | ===Treatment=== | ||
Measures which facilitate venous return such as head low posture, deep breathing and movement of extremities may be used. The use of epinephrine aggravates the shock like reaction. Methylene blue should be injected for treatment of severe methemoglobinemia with dyspnea. For treating cyanide poisoning, methylene blue is contraindicated where nitrites cause iatrogenic methemoglobinemia.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = AMYL NITRITE INHALANT [JAMES ALEXANDER CORPORATION] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c1b6e536-df5f-4f76-8e3c-6dc2f1e9975e | publisher = | date = | accessdate = 30 January 2014 }}</ref> | Measures which facilitate venous return such as head low posture, deep breathing and movement of extremities may be used. The use of [[epinephrine]] aggravates the shock like reaction. [[Methylene blue]] should be injected for treatment of severe [[methemoglobinemia]] with [[dyspnea]]. For treating [[cyanide poisoning]], [[methylene blue]] is contraindicated where nitrites cause iatrogenic [[methemoglobinemia]].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = AMYL NITRITE INHALANT [JAMES ALEXANDER CORPORATION] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c1b6e536-df5f-4f76-8e3c-6dc2f1e9975e | publisher = | date = | accessdate = 30 January 2014 }}</ref> | ||
==References== | ==References== | ||
Revision as of 23:44, 30 January 2014
| Amyl nitrite |
|---|
| Amyl nitrite tablet® FDA Package Insert |
| Indications and Usage |
| Dosage and Administration |
| Contraindications |
| Warnings and Precautions |
| Adverse Reactions |
| Drug Interactions |
| Overdosage |
| Description |
| Clinical Pharmacology |
| How Supplied/Storage and Handling |
| Patient Counseling Information |
| Labels and Packages |
| Clinical Trials |
| ClinicalTrials.gov |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]
Overdosage
Symptons
Inhaled doses of 5 to 10 drops of amyl nitrite may cause violent flushing of the face, accompanied by a feeling of imminent bursting of the head and very excessive heart action. The inhalation of larger amounts may produce a feeling of suffocation and muscular weakness. Symptons comparable to shock may be produced such as weakness, restlessness, sweating, pallor, nausea, vomiting, syncope and incontinence attributable to pooling of blood in the postarteriolar vessels and failure of the venous blood to return to the heart.
Treatment
Measures which facilitate venous return such as head low posture, deep breathing and movement of extremities may be used. The use of epinephrine aggravates the shock like reaction. Methylene blue should be injected for treatment of severe methemoglobinemia with dyspnea. For treating cyanide poisoning, methylene blue is contraindicated where nitrites cause iatrogenic methemoglobinemia.[1]
References
- ↑ "AMYL NITRITE INHALANT [JAMES ALEXANDER CORPORATION]". Retrieved 30 January 2014.