Thrombocytopenia causes: Difference between revisions
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===Causes in Alphabetical Order=== | ===Causes in Alphabetical Order=== | ||
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*[[5-azacytidine]] | |||
*[[Abciximab]] | |||
*[[Aclarubicin]] | |||
*[[Acquired pure megakaryocytic aplasia]] | |||
*[[Actinomycin D]] | |||
*[[Acute lymphoblastic leukemia]] | |||
*[[Acute myeloid leukemia]] | |||
*[[Acute promyelocytic leukemia]] | |||
*[[Acute respiratory distress syndrome]] | |||
*[[Aflibercept]] | |||
*[[Aggrastat]] | |||
*[[Aicardi goutieres syndrome]] | |||
*[[Albendazole]] | |||
*[[Alcohol]] | |||
*[[Alemtuzumab]] | |||
*[[Alport syndrome]] | |||
*[[Altretamine]] | |||
*[[Amiodarone]] | |||
*[[Amphotericin B]] | |||
*[[Amrinone]] | |||
*[[Amsacrine]] | |||
*[[Anagrelide]] | |||
*[[Anazolene]] | |||
*[[Anticardiolipin syndrome]] | |||
*[[Antiphospholipid syndrome]] | |||
*[[Antithymocyte globulin]] | |||
*[[Aplastic anemia]] | |||
*[[Ardeparin]] | |||
*[[Arias oculootoradial syndrome]] | |||
*[[Arsenic trioxide]] | |||
*[[Autoimmune lymphoproliferative syndrome type 1]] | |||
*[[Autoimmune lymphoproliferative syndrome type 2]] | |||
*[[Azathioprine]] | |||
*[[Bendamustine]] | |||
*[[Benoxaprofen]] | |||
*[[Bernard-Soulier syndrome]] | |||
*[[Bevacizumab]] | |||
*[[Bortezomib]] | |||
*[[Bosutinib]] | |||
*[[Brentuximab vedotin]] | |||
*[[Cabazitaxel]] | |||
*[[Capecitabine]] | |||
*[[Captopril]] | |||
*[[Carboplatin]] | |||
*[[Cardiac bypass]] | |||
*[[Carfilzomib]] | |||
*[[Carmustine]] | |||
*[[Caspofungin]] | |||
*[[Chediak-Higashi disease]] | |||
*[[Chemotherapy]] | |||
*[[Chlorambucil]] | |||
*[[Chloramphenicol]] | |||
*[[Cholesterol embolism]] | |||
*[[Chronic lymphocytic leukaemia]] | |||
*[[Chronic myeloid leukaemia]] | |||
*[[Cilazapril]] | |||
*[[Cimetidine]] | |||
*[[Cisplatin]] | |||
*[[Cladribine]] | |||
*[[Clofarabine]] | |||
*[[factor H|Complement factor H deficiency]] | |||
*[[Congenital amegakaryocytic thrombocytopenia (CAMT)]] | |||
*[[Cytomegalovirus]] | |||
*[[Cytosine arabinoside]] | |||
*[[Dacarbazine]] | |||
*[[Dasatinib]] | |||
*[[Daunorubicin]] | |||
*[[Decitabine]] | |||
*[[Dengue fever]] | |||
*[[Desferrioxamine]] | |||
*[[aminoaciduria|Dibasic aminoaciduria type 2]] | |||
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*[[Disseminated intravascular coagulation]] | |||
*[[Docetaxel]] | |||
*[[Doxorubicin]] | |||
*[[Drug-induced thrombocytopenia]] | |||
*[[Eclampsia]] | |||
*[[Efalizumab]] | |||
*[[Eflornithine]] | |||
*[[Ehrlichiosis]] | |||
*[[Elejalde syndrome - neuroectodermal melanolysosomal disease]] | |||
*[[Endocarditis]] | |||
*[[Enoxaparin]] | |||
*[[Epirubicin]] | |||
*[[Epstein syndrome]] | |||
*[[Epstein-Barr virus]] | |||
*[[Eptifibatide]] | |||
*[[Ethanol]] | |||
*[[Etoposide]] | |||
*[[Evans syndrome]] | |||
*[[Everolimus]] | |||
*[[Familial histiocytic reticulosis]] | |||
*[[Fanconi anaemia]] | |||
*[[Fechtner syndrome]] | |||
*[[Flucytocine]] | |||
*[[Fludarabine]] | |||
*[[Fluorouracil]] | |||
*[[Folate deficiency]] | |||
*[[Fondaparinux]] | |||
*[[Foscarnet]] | |||
*[[Ganciclovir]] | |||
*[[Gasser syndrome]] | |||
*[[GATA1-related cytopenia]] | |||
*[[Gaucher disease]] | |||
*[[Gemcitabine]] | |||
*[[Gemtuzumab ozogamicin]] | |||
*[[Glanzmann's thrombasthenia]] | |||
*[[Glycoprotein IIb/IIIa inhibitors]] | |||
*[[Gold salts]] | |||
*[[Grey platelet syndrome]] | |||
*[[Griscelli syndrome type 1]] | |||
*[[Guanidinium]] | |||
*[[Haem arginate]] | |||
*[[Hairy cell leukaemia]] | |||
*[[Hantavirus]] | |||
*[[HELLP syndrome]] | |||
*[[Hemolytic uremic syndrome]] | |||
*[[Heparin]] | |||
*[[Hepatitis C]] | |||
*[[Hepatosplenic T-cell lymphoma]] | |||
*[[Histiocytosis X]] | |||
*[[HIV]] | |||
*[[Holocarboxylase synthase deficiency]] | |||
*[[Human granulocytic ehrlichiosis]] | |||
*[[Human monocytotropic ehrlichiosis]] | |||
*[[Hydroxycarbamide]] | |||
*[[Hypersplenism]] | |||
*[[Ibritumomab tiuxetan]] | |||
*[[Ibrutinib]] | |||
*[[Idarubicin]] | |||
*[[Idiopathic thrombocytopenic purpura]] | |||
*[[Ifosfamide]] | |||
*[[Imatinib mesylate]] | |||
*[[Iminodipeptiduria]] | |||
*[[Immunodysregulation polyendocrinopathy and enteropathy, X-linked]] | |||
*[[Indomethacin]] | |||
*[[Infections]] | |||
*[[Infectious mononucleosis]] | |||
*[[Integrilin]] | |||
*[[Interferon alpha]] | |||
*[[Interleukin 10]] | |||
*[[Interleukin 2]] | |||
*[[Intra-aortic balloon pump placement]] | |||
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*[[Irinotecan]] | |||
*[[Iron deficiency]] | |||
*[[Isotretinoin]] | |||
*[[Isovaleric acidaemia]] | |||
*[[Ixabepilone]] | |||
*[[Jacobsen syndrome]] | |||
*[[Kasabach-Merritt syndrome]] | |||
*[[Lassa fever]] | |||
*[[Lenalidomide]] | |||
*[[Leptospirosis]] | |||
*[[Linezolid]] | |||
*[[Liver failure]] | |||
*[[Lomustine]] | |||
*[[Low molecular weight heparins]] | |||
*[[Lymphoma]] | |||
*[[Macrophage-activation syndrome]] | |||
*[[Malaria]] | |||
*[[Massive blood transfusion]] | |||
*[[May-Hegglin anomaly]] | |||
*[[Measles]] | |||
*[[MELAS]] | |||
*[[Melphalan]] | |||
*[[Mercaptopurine]] | |||
*[[Methotrexate]] | |||
*[[Methyldopa]] | |||
*[[Methyldopate]] | |||
*[[methylmalonic aciduria|Methylmalonic aciduria type 2]] | |||
*[[Methylphenidate]] | |||
*[[Micafungin]] | |||
*[[Mithramycin]] | |||
*[[Mitomycin C]] | |||
*[[Mitoxantrone]] | |||
*[[MMR vaccine]] | |||
*[[Montelukast]] | |||
*[[Moschcowitz syndrome]] | |||
*[[Mumps]] | |||
*[[Mycoplasma pneumonia]] | |||
*[[Myelodysplastic syndrome]] | |||
*[[Myelofibrosis]] | |||
*[[Myeloma]] | |||
*[[Nelarabine]] | |||
*[[Neonatal alloimmune thrombocytopenia]] | |||
*[[Neuroectodermal melanolysosomal disease]] | |||
*[[Niacin]] | |||
*[[niemann-pick disease|Niemann-Pick disease type b]] | |||
*[[Nilotinib]] | |||
*[[Nitisinone]] | |||
*[[Non-hodgkins lymphoma]] | |||
*[[Obinutuzumab]] | |||
*[[Oklahoma tick fever]] | |||
*[[Omacetaxine mepesuccinate]] | |||
*[[Omenn syndrome]] | |||
*[[Oxaliplatin]] | |||
*[[Paclitaxel]] | |||
*[[Pancytopenia]] | |||
*[[Panobinostat]] | |||
*[[Para-amino salicylic acid]] | |||
*[[Paraneoplastic syndrome]] | |||
*[[Paris-Trousseau thrombocytopenia]] | |||
*[[Paroxysmal nocturnal hemoglobinuria]] | |||
*[[Parvovirus]] | |||
*[[Pazopanib]] | |||
*[[Pemetrexed]] | |||
*[[Penicillamine]] | |||
*[[Pentamidine]] | |||
*[[Pentostatin]] | |||
*[[Phenylbutazone]] | |||
*[[Phenytoin]] | |||
*[[Pixantrone]] | |||
*[[Platelet glycoprotein 4 deficiency]] | |||
*[[Platelet glycoprotein Ib deficiency]] | |||
*[[Pomalidomide]] | |||
*[[Ponatinib]] | |||
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*[[Portal hypertension]] | |||
*[[Post-transfusion purpura]] | |||
*[[Pralatrexate]] | |||
*[[Pre-eclampsia]] | |||
*[[Procarbazine]] | |||
*[[Prolidase deficiency]] | |||
*[[Propionyl-CoA carboxylase deficiency]] | |||
*[[Proton pump inhibitors]] | |||
*[[Pulmonary embolism]] | |||
*[[Pyrimethamine]] | |||
*[[Q fever]] | |||
*[[Quinidine]] | |||
*[[Quinine]] | |||
*[[Radial aplasia-thrombocytopenia syndrome]] | |||
*[[Radiation therapy]] | |||
*[[Raltitrexed]] | |||
*[[Ranitidine]] | |||
*[[Regorafenib]] | |||
*[[ReoPro]] | |||
*[[Rifampicin]] | |||
*[[Rituximab]] | |||
*[[Romidepsin]] | |||
*[[Rubella]] | |||
*[[Ruxolitinib]] | |||
*[[Sea blue histiocytosis]] | |||
*[[Sebastian platelet syndrome]] | |||
*[[Septicaemia]] | |||
*[[Shwachman-Diamond syndrome]] | |||
*[[Sirolimus]] | |||
*[[Sitosterolemia]] | |||
*[[Snakebites]] | |||
*[[Sorafenib]] | |||
*[[Stiripentol]] | |||
*[[Strontium-89]] | |||
*[[Sulfasalazine]] | |||
*[[Sulfonamides]] | |||
*[[Sunitinib malate]] | |||
*[[Syphilis (congenital)]] | |||
*[[Systemic lupus erythematosus]] | |||
*[[TAR syndrome]] | |||
*[[Temozolomide]] | |||
*[[Temsirolimus]] | |||
*[[Teniposide]] | |||
*[[Thioguanine]] | |||
*[[Thiotepa]] | |||
*[[thrombocytopenia absent radius|Thrombocytopenia absent radius syndrome]] | |||
*[[Thrombotic thrombocytopenic purpura]] | |||
*[[Tick borne encephalitis]] | |||
*[[Ticlopidine]] | |||
*[[Tinzaparin]] | |||
*[[Tirofiban]] | |||
*[[Topotecan]] | |||
*[[Tositumomab iodine-131]] | |||
*[[toxic shock syndrome|Toxic shock syndrome (staphylococcal)]] | |||
*[[Trabectedin]] | |||
*[[Trimethoprim-sulfamethoxazole]] | |||
*[[Valganciclovir]] | |||
*[[Valproic acid]] | |||
*[[Vancomycin]] | |||
*[[Varicella]] | |||
*[[Vinflunine]] | |||
*[[Vinorelbine]] | |||
*[[Visceral leishmaniasis]] | |||
*[[Vitamin B12 deficiency]] | |||
*[[von Willebrand disease|Von willebrand disease, platelet type]] | |||
*[[Vorinostat]] | |||
*[[Werlhof disease]] | |||
*[[Wiskott-Aldrich syndrome]] | |||
*[[X-linked hyperimmunoglobulin M syndrome]] | |||
*[[Zinc]] | |||
*[[Ziv-aflibercept]] | |||
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Revision as of 17:15, 3 February 2014
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Thrombocytopenia Microchapters |
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Thrombocytopenia causes On the Web |
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Risk calculators and risk factors for Thrombocytopenia causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ogheneochuko Ajari, MB.BS, MS [2]
Overview
There are two broad mechanisms for the causes of thrombocytopenia: Reduced platelet production and increased platelet destruction. Thrombocytopenia is seen in a variety of infectious and genetic disorders as well as a side effect of a large list of medications.
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Common Causes
- Abruptio placentae[1]
- Bone marrow suppression (chemotherapy, irradiation)
- Cardica bypass[1]
- Chronic alcohol use
- Chronic liver disease[2]
- Common variable immunodeficiency[1]
- Congenital thrombocytopenia
- Connective tissue disorders (eg SLE, RA, antiphospholipid syndrome)[1]
- Disseminated intravascular coagulation[2]
- GP IIb/IIIa inhibitor[1]
- Hemolytic uremic syndrome
- Heparin-induced thrombocytopenia
- Immune thrombocytopenic purpura[3]
- Infections[2]
- Macrophage-activation syndrome[1]
- Medications[2]
- Preeclampsia
- Pregnancy[4]
- Pseudothrombocytopenia
- Thrombotic thrombocytopenic purpura[5]
Causes by Organ System
Causes in Alphabetical Order
Mendelian inherited conditions
- Autoimmune lymphoproliferative syndrome type 1
- Autoimmune lymphoproliferative syndrome type 2
- Radial aplasia-thrombocytopenia syndrome or Thrombocytopenia absent radius syndrome
- von Willebrand disease, platelet type
Autosomal dominant conditions
- Arias oculootoradial syndrome
- Complement factor H deficiency
- Fechtner syndrome
- May-Hegglin anomaly
- Platelet glycoprotein 4 deficiency
- Sebastian platelet syndrome
Autosomal recessive conditions
- Chediak-Higashi disease
- Dibasic aminoaciduria type 2
- Familial histiocytic reticulosis
- Fanconi anaemia
- Folate malabsorption hereditary
- Gaucher disease
- Griscelli syndrome type 1
- Histiocytosis X
- Holocarboxylase synthase deficiency
- Iminodipeptiduria
- Isovaleric acidaemia
- Methylmalonic aciduria type 2
- Neuroectodermal melanolysosomal disease
- Niemann-Pick disease type B
- Omenn syndrome
- Platelet glycoprotein Ib deficiency
- Propionyl-CoA carboxylase deficiency PCCA type
- Sea blue histiocytosis
- Shwachman-Diamond syndrome
Medication-induced
Thrombocytopenia associated with medications can be due to either a reduction in production of platelets or increased destruction.
List of potential etiologies:
|
Sulphonamides Drugs, hormones and mediators Aclarubicin Anazolene Antithymocyte globulin Arsenic trioxide
|
Guanidinium Haem arginate Methyldopate
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Para-amino salicylic acid Sulphasalazine Sunitinib malate |
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Stasi R (2012). "How to approach thrombocytopenia". Hematology Am Soc Hematol Educ Program. 2012: 191–7. doi:10.1182/asheducation-2012.1.191. PMID 23233580.
- ↑ 2.0 2.1 2.2 2.3 Greenberg EM, Kaled ES (2013). "Thrombocytopenia". Crit Care Nurs Clin North Am. 25 (4): 427–34, v. doi:10.1016/j.ccell.2013.08.003. PMID 24267279.
- ↑ Farid J, Gul N, Qureshi WU, Idris M (2012). "Clinical presentations in immune thrombocytopenic purpura". J Ayub Med Coll Abbottabad. 24 (2): 39–40. PMID 24397048.
- ↑ Nisha S, Amita D, Uma S, Tripathi AK, Pushplata S (2012). "Prevalence and characterization of thrombocytopenia in pregnancy in Indian women". Indian J Hematol Blood Transfus. 28 (2): 77–81. doi:10.1007/s12288-011-0107-x. PMC 3332269. PMID 23730013.
- ↑ Abdel Karim N, Haider S, Siegrist C, Ahmad N, Zarzour A, Ying J; et al. (2013). "Approach to management of thrombotic thrombocytopenic purpura at university of cincinnati". Adv Hematol. 2013: 195746. doi:10.1155/2013/195746. PMC 3876823. PMID 24396345.