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__NOTOC__
{{Labetalol}}
{{CMG}}; {{AE}} {{SS}}
'''''For patient information about Labetalol, click [[Labetalol (patient information)|here]]'''''
{{SB}}
==Overview==
'''Labetalol''' ('''Normodyne''', '''Trandate''', fixed combination with [[hydrochlorothiazide]]: '''Normozyde''') is an [[alpha blocker|alpha-1]] and[[beta blocker|beta adrenergic blocker]] used to treat [[hypertension|high blood pressure]].  It works by blocking these adrenergic receptors, which slows sinus [[heart]] rate, decreases peripheral vascular resistance.
It has a particular indication in the treatment of [[pregnancy-induced hypertension]].
==Category==
Cardiovascular Drugs:Beta blockers
==FDA Package Insert==
'''| [[Labetalol indications and usage|Indications and Usage]]'''
'''| [[Labetalol dosage and administration|Dosage and Administration]]'''
'''| [[Labetalol dosage forms and strengths|Dosage Forms and Strengths]]'''
'''| [[Labetalol contraindications|Contraindications]]'''
'''| [[Labetalol warnings and precautions|Warnings and Precautions]]'''
'''| [[Labetalol adverse reactions|Adverse Reactions]]'''
'''| [[Labetalol drug interactions|Drug Interactions]]'''
'''| [[Labetalol use in specific populations|Use in Specific Populations]]'''
'''| [[Labetalol overdosage|Overdosage]]'''
'''| [[Labetalol description|Description]]'''
'''| [[Labetalol clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Labetalol nonclinical toxicology|Nonclinical Toxicology]]'''
'''| [[Labetalol clinical studies|Clinical Studies]]'''
'''| [[Labetalol how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Labetalol patient counseling information|Patient Counseling Information]]'''
'''| [[Labetalol labels and packages|Labels and Packages]]'''
==Mechanism of Action==
==References==
{{Reflist|2}}
[[Category:Beta blockers]]
[[Category:Cardiovascular Drugs]]
[[Category:Drugs]]
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{drugbox
{{drugbox
| IUPAC_name = 2-hydroxy-5-[1-hydroxy-2-<br>(4-phenylbutan-2-ylamino)-ethyl]-benzamide
| IUPAC_name = 2-hydroxy-5-[1-hydroxy-2-<br>(4-phenylbutan-2-ylamino)-ethyl]-benzamide
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| bioavailability = 90-100%
| bioavailability = 90-100%
| protein_bound = 50%
| protein_bound = 50%
| metabolism = [[hepatic]] pass metabolism,  
| metabolism = [[hepatic]] pass metabolism,
| elimination_half-life = Tablet: 6-8 hours; IV: 5.5 hours
| elimination_half-life = Tablet: 6-8 hours; IV: 5.5 hours
| pregnancy_category = C<br>One of few drugs used for [[pregnancy-induced hypertension|PIH]]
| pregnancy_category = C<br>One of few drugs used for [[pregnancy-induced hypertension|PIH]]
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__NOTOC__
{{CMG}}
{{CMG}}


==Overview==
==Overview==

Revision as of 18:51, 4 February 2014

Labetalol
LABETALOL tablet® FDA Package Insert
Indications and Usage
Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
LABETALOL injection® FDA Package Insert
Indications and Usage
Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
Clinical Trials on Labetalol
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]

For patient information about Labetalol, click here

Synonyms / Brand Names:

Overview

Labetalol (Normodyne, Trandate, fixed combination with hydrochlorothiazide: Normozyde) is an alpha-1 andbeta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance.

It has a particular indication in the treatment of pregnancy-induced hypertension.

Category

Cardiovascular Drugs:Beta blockers

FDA Package Insert

| Indications and Usage | Dosage and Administration | Dosage Forms and Strengths | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages

Mechanism of Action

References

Template:WikiDoc Sources

Labetalol
Clinical data
Pregnancy
category
  • C
    One of few drugs used for PIH
Routes of
administration		oral iv
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability90-100%
Protein binding50%
Metabolismhepatic pass metabolism,
Elimination half-lifeTablet: 6-8 hours; IV: 5.5 hours
ExcretionExcreted in urine, not removed by hemodialysis
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC19H24N2O3
Molar mass328.406 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]

Overview

Labetalol (Normodyne, Trandate, fixed combination with hydrochlorothiazide: Normozyde) is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance.

It has a particular indication in the treatment of pregnancy-induced hypertension.

Administration

Labetalol is available in 100, 200, and 300 mg tablets and intravenously (only as Trandate) in 5 mg/ml solution. Adults taking tablets usually start with 100 mg two times a day, with a maximum of 2.4 g/day. In an emergency situation, this may be higher. IV doses are usually started at 20mg over 2 minutes. Additional doses of 40mg, then 80mg may be administered every ten minutes as needed. Additional 80mg doses can be given to a total maximum dose of 300 mg. Additionally, Labetalol can be administered by IV infusion at a rate of 2mg/minute, with a maximum dose of 300mg.

Side effects

Side effects may include:

  • Drowsiness
  • Fatigue
  • Weakness
  • Difficulty sleeping
  • Diminished sexual function
  • Scalp tingling which passes after time.
  • A rare but potentially lethal side effect is respiratory distress. If respiratory distress occurs after starting this drug, do not take additional dose; go to the emergency room and tell the clinician that you are having respiratory distress that you think may be due to the labetalol. Nurses: If your hospitalized patient on labetalol begins to have respiratory distress (may have no decrease in oximetry readings), stop the drug, initiate oxygen at 1-2 liters, and call the physician. Closely monitor the patient until all signs of respiratory distress are relieved.

Contraindications

Labetalol should not be used in patients that have asthma, congestive heart failure, any degree of heart blocks, slow heart rates or those in cardiogenic shock

References

  • Hodgson, Barbara B., and Kizior, Robert J. Saunders Nursing Drug Handbook 2006. St. Louis, MO: Elsevier, Saunders, 2006. bledsoe "prehospital emergency pharmacology" upper Saddle River, New Jersey: Pearson 2005


Template:WikiDoc Sources

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