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| ==Overview== | | ==Overview== |
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| '''Labetalol''' ('''Normodyne''', '''Trandate''', fixed combination with [[hydrochlorothiazide]]: '''Normozyde''') is an [[alpha blocker|alpha-1]] and[[beta blocker|beta adrenergic blocker]] used to treat [[hypertension|high blood pressure]]. It works by blocking these adrenergic receptors, which slows sinus [[heart]] rate, decreases peripheral vascular resistance. | | '''Labetalol''' ('''Normodyne''', '''Trandate''', fixed combination with [[hydrochlorothiazide]]: '''Normozyde''') is an [[alpha blocker|alpha-1]] and[[beta blocker|beta adrenergic blocker]] used to treat [[hypertension|high blood pressure]]. It works by blocking these adrenergic receptors, which slows sinus [[heart]] rate, decreases peripheral vascular resistance. |
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| [[Category:Cardiovascular Drugs]] | | [[Category:Cardiovascular Drugs]] |
| [[Category:Drugs]] | | [[Category:Drugs]] |
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| {{drugbox
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| | IUPAC_name = 2-hydroxy-5-[1-hydroxy-2-<br>(4-phenylbutan-2-ylamino)-ethyl]-benzamide
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| | image = Labetalol_svg.png
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| | CAS_number = 36894-69-6
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| | ATC_prefix = C07
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| | ATC_suffix = AG01
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| | PubChem = 3869
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| | DrugBank = APRD01062
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| | C = 19 |H = 24 |N = 2 |O = 3
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| | molecular_weight = 328.406 [[Gram|g]]/[[Mole (unit)|mol]]
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| | bioavailability = 90-100%
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| | protein_bound = 50%
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| | metabolism = [[hepatic]] pass metabolism,
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| | elimination_half-life = Tablet: 6-8 hours; IV: 5.5 hours
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| | pregnancy_category = C<br>One of few drugs used for [[pregnancy-induced hypertension|PIH]]
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| | legal_status = Rx-only
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| | routes_of_administration = oral [[intravenous|iv]]
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| | excretion = Excreted in urine, not removed by hemodialysis
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| }}
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| __NOTOC__
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| {{CMG}}
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| ==Overview==
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| '''Labetalol''' ('''Normodyne''', '''Trandate''', fixed combination with [[hydrochlorothiazide]]: '''Normozyde''') is an [[alpha blocker|alpha-1]] and [[beta blocker|beta adrenergic blocker]] used to treat [[hypertension|high blood pressure]]. It works by blocking these adrenergic receptors, which slows sinus [[heart]] rate, decreases peripheral vascular resistance.
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| It has a particular indication in the treatment of [[pregnancy-induced hypertension]].
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| ==Administration==
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| Labetalol is available in 100, 200, and 300 mg tablets and [[intravenous|intravenously]] (only as '''Trandate''') in 5 mg/ml solution. Adults taking tablets usually start with 100 mg two times a day, with a maximum of 2.4 g/day. In an emergency situation, this may be higher. IV doses are usually started at 20mg over 2 minutes. Additional doses of 40mg, then 80mg may be administered every ten minutes as needed. Additional 80mg doses can be given to a total maximum dose of 300 mg. Additionally, Labetalol can be administered by IV infusion at a rate of 2mg/minute, with a maximum dose of 300mg.
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| ==Side effects==
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| Side effects may include:
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| * [[Somnolence|Drowsiness]]
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| * [[Fatigue (physical)|Fatigue]]
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| * [[Weakness (medical)|Weakness]]
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| * [[Insomnia|Difficulty sleeping]]
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| * [[Sexual dysfunction|Diminished sexual function]]
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| * Scalp tingling which passes after time.
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| * A rare but potentially lethal side effect is respiratory distress. If respiratory distress occurs after starting this drug, do not take additional dose; go to the emergency room and tell the clinician that you are having respiratory distress that you think may be due to the labetalol. Nurses: If your hospitalized patient on labetalol begins to have respiratory distress (may have no decrease in oximetry readings), stop the drug, initiate oxygen at 1-2 liters, and call the physician. Closely monitor the patient until all signs of respiratory distress are relieved.
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| ==Contraindications==
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| Labetalol should not be used in patients that have asthma, congestive heart failure, any degree of heart blocks, slow heart rates or those in cardiogenic shock
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| ==References==
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| *Hodgson, Barbara B., and Kizior, Robert J. ''Saunders Nursing Drug Handbook 2006''. St. Louis, MO: Elsevier, Saunders, 2006. bledsoe "prehospital emergency pharmacology" upper Saddle River, New Jersey: Pearson 2005
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| {{beta blockers}}
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| [[Category:Beta blockers]]
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| [[Category:Drugs]]
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]
For patient information about Labetalol, click here
Synonyms / Brand Names:
Overview
Labetalol (Normodyne, Trandate, fixed combination with hydrochlorothiazide: Normozyde) is an alpha-1 andbeta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance.
It has a particular indication in the treatment of pregnancy-induced hypertension.
Category
Cardiovascular Drugs:Beta blockers
FDA Package Insert
| Indications and Usage
| Dosage and Administration
| Dosage Forms and Strengths
| Contraindications
| Warnings and Precautions
| Adverse Reactions
| Drug Interactions
| Use in Specific Populations
| Overdosage
| Description
| Clinical Pharmacology
| Nonclinical Toxicology
| Clinical Studies
| How Supplied/Storage and Handling
| Patient Counseling Information
| Labels and Packages
Mechanism of Action
References
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