Nebivolol drug interactions: Difference between revisions
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===Calcium Channel Blockers=== | ===Calcium Channel Blockers=== | ||
BYSTOLIC can exacerbate the effects of myocardial depressants or inhibitors of [[AV conduction]], such as certain [[calcium antagonist]]s (particularly of the phenylalkylamine [[[verapamil]]] and [[benzothiazepine]] [diltiazem] classes), or antiarrhythmic agents, such as [[disopyramide]]. | BYSTOLIC can exacerbate the effects of myocardial depressants or inhibitors of [[AV conduction]], such as certain [[calcium antagonist]]s (particularly of the phenylalkylamine [ [[verapamil]] ] and [[benzothiazepine]] [diltiazem] classes), or antiarrhythmic agents, such as [[disopyramide]]. | ||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = BYSTOLIC (NEBIVOLOL HYDROCHLORIDE) TABLET [FOREST LABORATORIES, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=8b8ad213-1dc8-454e-a524-075685c0e1a8 | publisher = | date = | accessdate = 4 February 2014 }}</ref> | <ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = BYSTOLIC (NEBIVOLOL HYDROCHLORIDE) TABLET [FOREST LABORATORIES, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=8b8ad213-1dc8-454e-a524-075685c0e1a8 | publisher = | date = | accessdate = 4 February 2014 }}</ref> | ||
Revision as of 20:32, 4 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]
Drug Interactions
CYP2D6 Inhibitors
Use caution when BYSTOLIC is co-administered with CYP2D6 inhibitors (quinidine, propafenone, fluoxetine, paroxetine, etc.) [see Clinical Pharmacology (12.5)].
Hypotensive Agents
Do not use BYSTOLIC with other β-blockers. Closely monitor patients receiving catecholamine-depleting drugs, such as reserpine or guanethidine, because the added β-blocking action of BYSTOLIC may produce excessive reduction of sympathetic activity. In patients who are receiving BYSTOLIC and clonidine, discontinue BYSTOLIC for several days before the gradual tapering of clonidine.
Digitalis Glycosides
Both digitalis glycosides and β-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia.
Calcium Channel Blockers
BYSTOLIC can exacerbate the effects of myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (particularly of the phenylalkylamine [ verapamil ] and benzothiazepine [diltiazem] classes), or antiarrhythmic agents, such as disopyramide.
References
- ↑ "BYSTOLIC (NEBIVOLOL HYDROCHLORIDE) TABLET [FOREST LABORATORIES, INC.]". Retrieved 4 February 2014.