Clonidine: Difference between revisions
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Revision as of 02:08, 5 February 2014
Synonyms / Brand Names:
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Dosing and Administration
Adults: The dose of Clonidine hydrochloride must be adjusted according to the patient’s individual blood pressure response. The following is a general guide to its administration.
Initial Dose: 0.1 mg tablet twice daily (morning and bedtime). Elderly patients may benefit from a lower initial dose.
Maintenance Dose: Further increments of 0.1 mg per day may be made at weekly intervals if necessary until the desired response is achieved. Taking the larger portion of the oral daily dose at bedtime may minimize transient adjustment effects of dry mouth and drowsiness. The therapeutic doses most commonly employed have ranged from 0.2 mg to 0.6 mg per day given in divided doses. Studies have indicated that 2.4 mg is the maximum effective daily dose, but doses as high as this have rarely been employed.
Renal Impairment: Dosage must be adjusted according to the degree of impairment, and patients should be carefully monitored. Since only a minimal amount of Clonidine is removed during routine hemodialysis, there is no need to give supplemental Clonidine following dialysis.
FDA Package Insert Resources
Indications, Contraindications, Side Effects, Drug Interactions, etc.
Calculate Creatine Clearance
On line calculator of your patients Cr Cl by a variety of formulas.
Convert pounds to Kilograms
On line calculator of your patients weight in pounds to Kg for dosing estimates.
Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information
Trial Resources
Ongoing Trials, Trial Results
Guidelines & Evidence Based Medicine Resources
US National Guidelines, Cochrane Collaboration, etc.
Media Resources
Slides, Video, Images, MP3, Podcasts, etc.
Patient Resources
Discussion Groups, Handouts, Blogs, News, etc.
International Resources
en Español
FDA Package Insert Resources
Indications
Contraindications
Side Effects
Drug Interactions
Precautions
Overdose
Instructions for Administration
How Supplied
Pharmacokinetics and Molecular Data
FDA label
FDA on Clonidine
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Publication Resources
Most Recent Articles on Clonidine
Review Articles on Clonidine
Articles on Clonidine in N Eng J Med, Lancet, BMJ
WikiDoc State of the Art Review
Textbook Information on Clonidine
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Trial Resources
Ongoing Trials with Clonidine at Clinical Trials.gov
Trial Results with Clonidine
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Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Clonidine
Cochrane Collaboration on Clonidine
Cost Effectiveness of Clonidine
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Media Resources
Powerpoint Slides on Clonidine
Images of Clonidine
Podcasts & MP3s on Clonidine
Videos on Clonidine
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Patient Resources
Patient Information from National Library of Medicine
Patient Resources on Clonidine
Discussion Groups on Clonidine
Patient Handouts on Clonidine
Blogs on Clonidine
Clonidine in the News
Clonidine in the Marketplace
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International Resources
Clonidine en Español
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Adapted from the FDA Package Insert.