CLONIDINE patch drug interactions: Difference between revisions
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Clonidine may potentiate the CNS-depressive effects of alcohol, barbiturates or other sedating drugs. If a patient receiving clonidine is also taking [[tricyclic antidepressants]], the [[hypotensive]] effect of clonidine may be reduced, necessitating an increase in the clonidine dose. If a patient receiving clonidine is also taking [[neuroleptics]], orthostatic regulation disturbances (e.g., [[orthostatic hypotension]], [[dizziness]], [[fatigue]]) may be induced or exacerbated. | |||
Monitor heart rate in patients receiving clonidine concomitantly with agents known to affect sinus node function or AV nodal conduction, e.g., [[digitalis]], [[calcium channel blockers]] and [[beta-blockers]]. [[Sinus bradycardia]] resulting in hospitalization and pacemaker insertion has been reported in association with the use of clonidine concomitantly with [[diltiazem]] or [[verapamil]]. | |||
[[Amitriptyline]] in combination with clonidine enhances the manifestation of corneal lesions in rats.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = CLONIDINE PATCH [MYLAN PHARMACEUTICALS INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7adfc439-e6d0-4593-87dd-0eef36d33c6d | publisher = | date = | accessdate = 5 February 2014 }}</ref> | |||
==References== | ==References== | ||
Latest revision as of 01:47, 6 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]
For patient information, click here.
Interactions
Clonidine may potentiate the CNS-depressive effects of alcohol, barbiturates or other sedating drugs. If a patient receiving clonidine is also taking tricyclic antidepressants, the hypotensive effect of clonidine may be reduced, necessitating an increase in the clonidine dose. If a patient receiving clonidine is also taking neuroleptics, orthostatic regulation disturbances (e.g., orthostatic hypotension, dizziness, fatigue) may be induced or exacerbated.
Monitor heart rate in patients receiving clonidine concomitantly with agents known to affect sinus node function or AV nodal conduction, e.g., digitalis, calcium channel blockers and beta-blockers. Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported in association with the use of clonidine concomitantly with diltiazem or verapamil.
Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions in rats.[1]
References
- ↑ "CLONIDINE PATCH [MYLAN PHARMACEUTICALS INC.]". Retrieved 5 February 2014.