Valproate sodium overdosage: Difference between revisions
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== | ==Overdosage== | ||
Overdosage with valproate may result in somnolence, heart block, and deep coma. Fatalities have been reported; however patients have recovered from valproate serum concentrations as high as 2120 mcg/mL. | |||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = DEPACON (VALPROATE SODIUM) INJECTION [ABBVIE INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=da030cbb-40f6-4805-9883-0d8945afbcc3#section-1 | publisher = | date = | accessdate = }}</ref> | In overdose situations, the fraction of drug not bound to protein is high and hemodialysis or tandem hemodialysis plus hemoperfusion may result in significant removal of drug. General supportive measures should be applied with particular attention to the maintenance of adequate urinary output. | ||
Naloxone has been reported to reverse the CNS depressant effects of valproate overdosage. Because naloxone could theoretically also reverse the antiepilepsy effects of valproate, it should be used with caution in patients with epilepsy.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = DEPACON (VALPROATE SODIUM) INJECTION [ABBVIE INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=da030cbb-40f6-4805-9883-0d8945afbcc3#section-1 | publisher = | date = | accessdate = }}</ref> | |||
==References== | ==References== |
Latest revision as of 20:47, 6 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overdosage
Overdosage with valproate may result in somnolence, heart block, and deep coma. Fatalities have been reported; however patients have recovered from valproate serum concentrations as high as 2120 mcg/mL.
In overdose situations, the fraction of drug not bound to protein is high and hemodialysis or tandem hemodialysis plus hemoperfusion may result in significant removal of drug. General supportive measures should be applied with particular attention to the maintenance of adequate urinary output.
Naloxone has been reported to reverse the CNS depressant effects of valproate overdosage. Because naloxone could theoretically also reverse the antiepilepsy effects of valproate, it should be used with caution in patients with epilepsy.[1]
References
Adapted from the FDA Package Insert.