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Stabilization phase (1-2 months): ❑ Transition when patient has: No withdrawal symptoms Minimal or no side effects No uncontrollable craving for opioid agonists ❑ Begin with buprenorphine/naloxone combination, increasing dose by 2/0.5-4/1 mg per week till stabilization is achieved, most stabilizing at 16/4-24/6 mg} ❑ As patient stabilizes, transition to alternate day or every third day regimen by doubling and tripling daily doses respectively Maintenance phase: ❑ Maintain at same dose as daily stabilization dose ❑ Decide total treatment duration based on: Stable housing & income Patients motivation, doctors comfort in tapering Presence of psychosocial support Absence of legal support Other drugs & alcohol abuse