Valproic acid: Difference between revisions
Gerald Chi (talk | contribs) |
Gerald Chi (talk | contribs) mNo edit summary |
||
Line 4: | Line 4: | ||
{{CMG}} | {{CMG}} | ||
'''''For patient information about | '''''For patient information about Valproic acid, click [[Valproic Acid (patient information)|here]]''''' | ||
{{SB}} Depakene<sup>®</sup>, Stavzor<sup>®</sup> | {{SB}} Depakene<sup>®</sup>, Stavzor<sup>®</sup> | ||
Line 20: | Line 20: | ||
====DEPAKENE (valproic acid) capsule/solution==== | ====DEPAKENE (valproic acid) capsule/solution==== | ||
''' [[ | ''' [[Valproic acid capsule/solution indications and usage|Indications and Usage]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution dosage and administration|Dosage and Administration]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution dosage forms and strengths|Dosage Forms and Strengths]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution contraindications|Contraindications]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution warnings and precautions|Warnings and Precautions]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution adverse reactions|Adverse Reactions]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution drug interactions|Drug Interactions]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution use in specific populations|Use in Specific Populations]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution overdosage|Overdosage]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution description|Description]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution clinical pharmacology|Clinical Pharmacology]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution nonclinical toxicology|Nonclinical Toxicology]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution clinical studies|Clinical Studies]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution how supplied storage and handling|How Supplied/Storage and Handling]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution patient counseling information|Patient Counseling Information]]''' | ||
'''| [[ | '''| [[Valproic acid capsule/solution labels and packages|Labels and Packages]]''' | ||
====STAVZOR (valproic acid) capsule, delayed release==== | ====STAVZOR (valproic acid) capsule, delayed release==== | ||
''' [[ | ''' [[Valproic acid capsule delayed release indications and usage|Indications and Usage]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release dosage and administration|Dosage and Administration]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release dosage forms and strengths|Dosage Forms and Strengths]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release contraindications|Contraindications]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release warnings and precautions|Warnings and Precautions]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release adverse reactions|Adverse Reactions]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release drug interactions|Drug Interactions]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release use in specific populations|Use in Specific Populations]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release overdosage|Overdosage]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release description|Description]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release clinical pharmacology|Clinical Pharmacology]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release nonclinical toxicology|Nonclinical Toxicology]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release clinical studies|Clinical Studies]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release how supplied storage and handling|How Supplied/Storage and Handling]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release patient counseling information|Patient Counseling Information]]''' | ||
'''| [[ | '''| [[Valproic acid capsule delayed release labels and packages|Labels and Packages]]''' | ||
==Mechanism of Action== | ==Mechanism of Action== |
Revision as of 21:39, 6 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
For patient information about Valproic acid, click here
Synonyms / Brand Names: Depakene®, Stavzor®
Overview
Valproic acid (VPA, Valproate), an acidic chemical compound, has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder, and, less commonly, major depression. It is also used to treat migraine headaches. VPA is a liquid at room temperature, but it can be reacted with a base such as sodium hydroxide to form the salt sodium valproate, which is a solid. The acid, salt, or a mixture of the two (valproate semisodium) are marketed under the various brand names Depakote, Depakote ER, Depakene, Depakine, Depakine Crono (extended release in Spain), Depacon, Dépakine, Valparin, and Stavzor.
Approved uses of the various formulations vary by country; e.g., valproate semisodium is used as a mood stabilizer and also in the US as an anticonvulsant.
VPA is a histone deacetylase inhibitor and is under investigation for treatment of HIV and various cancers.[1]
FDA Package Insert
DEPAKENE (valproic acid) capsule/solution
Indications and Usage | Dosage and Administration | Dosage Forms and Strengths | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages
STAVZOR (valproic acid) capsule, delayed release
Indications and Usage | Dosage and Administration | Dosage Forms and Strengths | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages
Mechanism of Action
Valproate is believed to affect the function of the neurotransmitter GABA in the human brain, making it an alternative to lithium salts in treatment of bipolar disorder. Its mechanism of action includes enhanced neurotransmission of GABA (by inhibiting GABA transaminase, which breaks down GABA). However, several other mechanisms of action in neuropsychiatric disorders have been proposed for valproic acid in recent years.[2]
Valproic acid also blocks voltage-gated sodium channels and T-type calcium channels. These mechanisms make valproic acid a broad-spectrum anticonvulsant drug.
Valproic acid is an inhibitor of the enzyme histone deacetylase 1 (HDAC1), hence it is a histone deacetylase inhibitor.
References
- ↑ PMID 22318143 (PMID 22318143)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 17514356 (PMID 17514356)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand