Thrombocytopenia causes: Difference between revisions
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{|style="width:80%; height:100px" border="1" | {|style="width:80%; height:100px" border="1" | ||
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular''' | |style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular''' | ||
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | | |style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Disseminated intravascular coagulation]], [[endocarditis]], [[pulmonary embolism]] | ||
|- | |- | ||
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning''' | |bgcolor="LightSteelBlue"| '''Chemical/Poisoning''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Strontium-89]],[[zinc]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Dermatologic''' | | '''Dermatologic''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Cholesterol embolism]], [[Elejalde syndrome]], [[Griscelli syndrome|Griscelli syndrome type 1]], [[neuroectodermal melanolysosomal disease]], [[post-transfusion purpura]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Drug Side Effect''' | | '''Drug Side Effect''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[5-azacytidine]], [[abciximab]], [[aclarubicin]], [[actinomycin D]], [[aflibercept]], [[aggrastat]], [[albendazole]], [[alemtuzumab]], [[altretamine]], [[amiodarone]], [[amphotericin B]], [[amrinone]], [[amsacrine]], [[anagrelide]], [[anazolene]], [[anti-thymocyte globulin]], [[ardeparin]], [[azathioprine]], [[bendamustine]], [[benoxaprofen]], [[bevacizumab]], [[bortezomib]], [[bosutinib]], [[brentuximab vedotin]], [[cabazitaxel]], [[capecitabine]], [[captopril]], [[carboplatin]], [[carfilzomib]], [[carmustine]], [[caspofungin]], [[chlorambucil]], [[chloramphenicol]], [[cilazapril]], [[cimetidine]], [[cisplatin]], [[cladribine]], [[clofarabine]], [[cytosine arabinoside]], [[dacarbazine]], [[dasatinib]], [[daunorubicin]], [[decitabine]], [[desferrioxamine]], [[docetaxel]], [[doxorubicin]], [[drug-induced thrombocytopenia]], [[efalizumab]], [[eflornithine]], [[enoxaparin]], [[epirubicin]], [[eptifibatide]], [[etoposide]], [[everolimus]], [[flucytosine]], [[fludarabine]], [[fluorouracil]], [[fondaparinux]], [[foscarnet]], [[ganciclovir]], [[gemcitabine]], [[gemtuzumab ozogamicin]], [[glycoprotein IIb/IIIa inhibitors]], [[gold salts]], [[guanidinium]], [[haem arginate]], [[heparin]], [[hydroxycarbamide]], [[ibitumomab tiuxetan]], [[ibrutinib]], [[idarubicin]], [[ifosfamide]], [[imatinib mesylate]], [[indomethacin]], [[integrilin]], [[interferon alpha]], [[interleukin 10]], [[interleukin 2]], [[irinotecan]], [[isotretinoin]], [[ixabepilone]], [[lenalidomide]], [[linezolid]], [[lomustine]], [[low molecular weight heparin]]s, [[melphalan]], [[mercaptopurine]], [[methotrexate]], [[methyldopa]], [[methyldopate]], [[methylphenidate]], [[micafungin]], [[mithramycin]], [[mitomycin C]], [[mitoxantrone]], [[MMR vaccine]], [[montelukast]], [[nelarabine]], [[niacin]], [[nilotinib]], [[nitisinone]], [[obinutuzumab]], [[omacetaxine mepesuccinate]], [[oxaliplatin]], [[paclitaxel]], [[panobinostat]], [[para-amino salicylic acid]], [[pazopanib]], [[pemetrexed]], [[penicillamine]], [[pentamidine]], [[pentostatin]], [[phenylbutazone]], [[phenytoin]], [[pixantrone]], [[pomalidomide]], [[ponatinib]], [[pralatrexate]], [[procarbazine]], [[proton pump inhibitors]], | ||
[[pyrimethamine]], [[quinidine]], [[quinine]], [[raltitrexed]], [[ranitidine]], [[regorafenib]], [[reoPro]], [[rifampicin]], [[rituximab]], [[romidepsin]], [[ruxolitinib]], [[sirolimus]], [[sorafenib]], [[stiripentol]], [[sulfasalazine]], [[sulfonamides]], [[sunitinib malate]], [[temozolomide]], [[temsirolimus]], [[teniposide]], [[thioguanine]], [[thiotepa]], [[ticlopidine]], [[tinzaparin]], [[tirofiban]], [[topotecan]], [[tositumomab iodine-131]], [[trabectedin]], [[trimethoprim-sulfamethoxazole]], [[valganciclovir]], [[valproic acid]], [[vancomycin]], [[vinflunine]], [[vinorelbine]], [[vorinostat]], [[ziv-aflibercept]] | |||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Ear Nose Throat''' | | '''Ear Nose Throat''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Alport syndrome]], [[Arias oculootoradial syndrome]], [[Epstein's syndrome]], [[Fechtner syndrome]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Endocrine''' | | '''Endocrine''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Immunodysregulation polyendocrinopathy and enteropathy, X-linked]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Gastroenterologic''' | | '''Gastroenterologic''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[aminoaciduria|Dibasic aminoaciduria type 2]], [[liver failure]], [[Niemann-Pick disease|Niemann-Pick disease type b]], [[portal hypertension]], [[Shwachman-Diamond syndrome]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Genetic''' | | '''Genetic''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Aicardi-Goutieres syndrome]], [[Alport syndrome]], [[Chediak-Higashi disease]], [[factor H|complement factor H deficiency]], [[Elejalde syndrome]], [[Fanconi anaemia]], [[Fechtner syndrome]], [[Griscelli syndrome|Griscelli syndrome type 1]], [[holocarboxylase synthase deficiency]], [[iminodipeptiduria]], [[immunodysregulation polyendocrinopathy and enteropathy, X-linked]], [[Jacobsen syndrome]], [[MELAS]], [[neuroectodermal melanolysosomal disease]], [[Niemann-Pick disease|Niemann-Pick disease type b]], [[Omenn syndrome]], [[Paris-Trousseau thrombocytopenia]], [[Shwachman-Diamond syndrome]], [[TAR syndrome]], [[TAR syndrome|Thrombocytopenia absent radius syndrome]], [[Von Willebrand disease|Von Willebrand disease, platelet type]], [[Wiskott-Aldrich syndrome]], [[X-linked hyperimmunoglobulin M syndrome]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Hematologic''' | | '''Hematologic''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Acquired pure megakaryocytic aplasia]], [[aplastic anemia]], [[Bernard-Soulier syndrome]], [[congenital amegakaryocytic thrombocytopenia (CAMT)]], [[disseminated intravascular coagulation]], [[Epstein's syndrome]], [[familial histiocytic reticulosis]], [[Gasser syndrome]], [[GATA1-related cytopenia]], [[Glanzmann's thrombasthenia]], [[grey platelet syndrome]], [[hemolytic uremic syndrome]], [[histiocytosis X]], [[hypersplenism]], [[idiopathic thrombocytopenic purpura]], [[Jacobsen syndrome]], [[Kasabach-Merritt syndrome]], [[May-Hegglin anomaly]], [[Moschcowitz syndrome]], [[myelodysplastic syndrome]], [[myelofibrosis]], [[neonatal alloimmune thrombocytopenia]], [[pancytopenia]], [[Paris-Trousseau thrombocytopenia]], [[paroxysmal nocturnal hemoglobinuria]], [[post-transfusion purpura]], [[pulmonary embolism]], [[radial aplasia-thrombocytopenia syndrome]], [[Sebastian platelet syndrome]], [[Shwachman-Diamond syndrome]], [[thrombotic thrombocytopenic purpura]], [[Von Willebrand disease|Von Willebrand disease, platelet type]], [[Werlhof disease]], [[Wiskott-Aldrich syndrome]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Iatrogenic''' | | '''Iatrogenic''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[coronary artery bypass surgery|Cardiac bypass]], [[chemotherapy]], [[intra-aortic balloon pump placement]], [[blood transfusion|massive blood transfusion]], [[radiation therapy]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Infectious Disease''' | | '''Infectious Disease''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Congenital syphilis]], [[cytomegalovirus]], [[Dengue fever]], [[ehrlichiosis]], [[Epstein-Barr virus]], [[hantavirus]], [[hepatitis C]], | ||
[[HIV]], [[human granulocytic ehrlichiosis]], [[human monocytotropic ehrlichiosis]], [[infections]], [[infectious mononucleosis]], [[lassa fever]], [[leptospirosis]], [[malaria]], [[measles]], [[mumps]], [[mycoplasma pneumonia]], [[Oklahoma tick fever]], [[parvovirus]], [[Q fever]], [[rubella]], [[septicaemia]], [[tick borne encephalitis]], [[toxic shock syndrome|toxic shock syndrome (staphylococcal)]], [[varicella]], [[visceral leishmaniasis]] | |||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Musculoskeletal/Orthopedic''' | | '''Musculoskeletal/Orthopedic''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Arias oculootoradial syndrome]], [[cholesterol embolism]], [[radial aplasia-thrombocytopenia syndrome]], [[TAR syndrome]], [[TAR syndrome|thrombocytopenia absent radius syndrome]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Neurologic''' | | '''Neurologic''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Aicardi-Goutieres syndrome]], [[Jacobsen syndrome]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Nutritional/Metabolic''' | | '''Nutritional/Metabolic''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[aminoaciduria|Dibasic aminoaciduria type 2]], [[folate deficiency]], [[Gaucher disease]], [[holocarboxylase synthase deficiency]], [[iminodipeptiduria]], [[iron deficiency]], [[isovaleric acidaemia]], [[methylmalonic aciduria type 2]], [[platelet glycoprotein 4 deficiency]], [[platelet glycoprotein Ib deficiency]], [[prolidase deficiency]], [[propionyl-CoA carboxylase deficiency]], [[sea blue histiocytosis]], [[sitosterolemia]], [[vitamin B12 deficiency]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Obstetric/Gynecologic''' | | '''Obstetric/Gynecologic''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Eclampsia]], [[HELLP syndrome]], [[pre-eclampsia]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Oncologic''' | | '''Oncologic''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Acute lymphoblastic leukemia]], [[acute myeloid leukemia]], [[acute promyelocytic leukemia]], [[chronic lymphocytic leukaemia]], [[chronic myeloid leukaemia]], [[hairy cell leukaemia]], [[hepatosplenic T-cell lymphoma]], [[histiocytosis X]], [[Kasabach-Merritt syndrome]], [[lymphoma]], [[myeloma]], [[Non-Hodgkins lymphoma]], [[paraneoplastic syndrome]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Ophthalmologic''' | | '''Ophthalmologic''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Arias oculootoradial syndrome]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Overdose/Toxicity''' | | '''Overdose/Toxicity''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Alcohol]], [[arsenic trioxide]], [[ethanol]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Pulmonary''' | | '''Pulmonary''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Acute respiratory distress syndrome]], [[Niemann-Pick disease|Niemann-Pick disease type b]], [[pulmonary embolism]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Renal/Electrolyte''' | | '''Renal/Electrolyte''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Alport syndrome]], [[cholesterol embolism]], [[aminoaciduria|Dibasic aminoaciduria type 2]], [[Epstein's syndrome]], [[Fechtner syndrome]], [[hemolytic uremic syndrome]] | ||
|- | |- | ||
|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Rheumatology/Immunology/Allergy''' | | '''Rheumatology/Immunology/Allergy''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Anticardiolipin syndrome]], [[antiphospholipid syndrome]], [[autoimmune lymphoproliferative syndrome type 1]], [[autoimmune lymphoproliferative syndrome type 2]], [[factor H|complement factor H deficiency]], [[Evans syndrome]], [[macrophage-activation syndrome]], [[neonatal alloimmune thrombocytopenia]], [[Omenn syndrome]], [[paraneoplastic syndrome]], [[systemic lupus erythematosus]], [[Wiskott-Aldrich syndrome]], [[X-linked hyperimmunoglobulin M syndrome]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Miscellaneous''' | | '''Miscellaneous''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Snakebites]] | ||
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|} | |} |
Revision as of 04:20, 10 February 2014
Thrombocytopenia Microchapters |
Diagnosis |
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Treatment |
Case Studies |
Thrombocytopenia causes On the Web |
American Roentgen Ray Society Images of Thrombocytopenia causes |
Risk calculators and risk factors for Thrombocytopenia causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ogheneochuko Ajari, MB.BS, MS [2]
Overview
There are two broad mechanisms for the causes of thrombocytopenia: Reduced platelet production and increased platelet destruction. Thrombocytopenia is seen in a variety of infectious and genetic disorders as well as a side effect of a large list of medications.
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Common Causes
- Abruptio placentae[1]
- Bone marrow suppression (chemotherapy, irradiation)
- Cardica bypass[1]
- Chronic alcohol use
- Chronic liver disease[2]
- Common variable immunodeficiency[1]
- Congenital thrombocytopenia
- Connective tissue disorders (eg SLE, RA, antiphospholipid syndrome)[1]
- Disseminated intravascular coagulation[2]
- GP IIb/IIIa inhibitor[1]
- Hemolytic uremic syndrome
- Heparin-induced thrombocytopenia
- Immune thrombocytopenic purpura[3]
- Infections[2]
- Macrophage-activation syndrome[1]
- Medications[2]
- Preeclampsia
- Pregnancy[4]
- Pseudothrombocytopenia
- Thrombotic thrombocytopenic purpura[5]
Causes by Organ System
Causes in Alphabetical Order
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Stasi R (2012). "How to approach thrombocytopenia". Hematology Am Soc Hematol Educ Program. 2012: 191–7. doi:10.1182/asheducation-2012.1.191. PMID 23233580.
- ↑ 2.0 2.1 2.2 2.3 Greenberg EM, Kaled ES (2013). "Thrombocytopenia". Crit Care Nurs Clin North Am. 25 (4): 427–34, v. doi:10.1016/j.ccell.2013.08.003. PMID 24267279.
- ↑ Farid J, Gul N, Qureshi WU, Idris M (2012). "Clinical presentations in immune thrombocytopenic purpura". J Ayub Med Coll Abbottabad. 24 (2): 39–40. PMID 24397048.
- ↑ Nisha S, Amita D, Uma S, Tripathi AK, Pushplata S (2012). "Prevalence and characterization of thrombocytopenia in pregnancy in Indian women". Indian J Hematol Blood Transfus. 28 (2): 77–81. doi:10.1007/s12288-011-0107-x. PMC 3332269. PMID 23730013.
- ↑ Abdel Karim N, Haider S, Siegrist C, Ahmad N, Zarzour A, Ying J; et al. (2013). "Approach to management of thrombotic thrombocytopenic purpura at university of cincinnati". Adv Hematol. 2013: 195746. doi:10.1155/2013/195746. PMC 3876823. PMID 24396345.