Dimetotiazine: Difference between revisions

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m Changed protection level for "Dimetotiazine" ([Edit=Allow only autoconfirmed users] (expires 02:09, 19 February 2014 (UTC)) [Move=Allow only autoconfirmed users] (expires 02:09, 19 February 2014 (UTC)))
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__NOTOC__
{{Oxetoron}}
{{CMG}}; {{AE}} {{PB}}
'''''For patient information, click [[Oxetoron (patient information)|here]]'''''.
{{Drugbox
{{Drugbox
| IUPAC_name       = 10-(2-dimethylaminopropyl)-N,N-dimethylphenothiazine-2-sulfonamide
| Verifiedfields = changed
| image             = Dimetotiazine.png  
| verifiedrevid = 443778442
| CAS_number       = 7456-24-8
| IUPAC_name = 10-(2-dimethylaminopropyl)-N,N-dimethylphenothiazine-2-sulfonamide
| CAS_supplemental  =
| image = Dimetotiazine.png
| ATC_prefix       =  
 
| ATC_suffix       =  
<!--Clinical data-->
| ATC_supplemental  =
| tradename = 
| PubChem           = 3089
| Drugs.com = {{drugs.com|international|dimetotiazine}}
| DrugBank         =  
| pregnancy_AU =<! -- A / B1 / B2 / B3 / C / D / X -->
| chemical_formula  =
| pregnancy_US =<! -- A / B            / C / D / X -->
| pregnancy_category = 
| legal_AU =<! -- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA =<! -- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK =<! -- GSL, P, POM, CD, or Class A, B, C -->
| legal_US =<! -- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status = Rx-only
| routes_of_administration = Oral
 
<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
| excretion = 
 
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 7456-24-8
| ATC_prefix = N02
| ATC_suffix = CX05
| ATC_supplemental =  
| PubChem = 3089
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 1FTA475ZDB
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07854
|  ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 2979
|  InChI = 1/C19H25N3O2S2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5/h6-12,14H,13H2,1-5H3
|  InChIKey = VWNWVCJGUMZDIU-UHFFFAOYAN
|  StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C19H25N3O2S2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5/h6-12,14H,13H2,1-5H3
|  StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = VWNWVCJGUMZDIU-UHFFFAOYSA-N
 
<!--Chemical data-->
| chemical_formula =  
| C=19 | H=25 | N=3 | O=2 | S=2  
| C=19 | H=25 | N=3 | O=2 | S=2  
| molecular_weight = 391.55 g/mol
| molecular_weight = 391.55 g/mol
| smiles           = CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)S(=O)(=O)N(C)C)N(C)C
| smiles = CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)S(=O)(=O)N(C)C)N(C)C
| bioavailability  =
| protein_bound    =
| metabolism        =
| elimination_half-life =
| excretion        =
| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US      =  <!-- A / B            / C / D / X -->
| pregnancy_category= 
| legal_AU =  <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA =  <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK =  <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US =  <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status      = Rx-only
| routes_of_administration = Oral
}}
}}
{{CMG}}




==Overview==
'''Dimetotiazine''' ([[International Nonproprietary Name|INN]]) is a [[phenothiazine]]. It is a [[serotonin antagonist]] and [[histamine antagonist]].<ref name="pmid8564192">{{cite journal |author=Shimazawa M, Hara H, Watano T, Sukamoto T |title=Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats |journal=Br. J. Pharmacol. |volume=115 |issue=8 |pages=1359–68 |date=August 1995 |pmid=8564192 |pmc=1908864 |doi= |url=}}</ref>
==Category==


'''Dimetotiazine''' ([[International Nonproprietary Name|INN]]) is a phenothiazine.
[[Antimigraine]] agent


{{Antimigraine preparations}}
{{Antimigraine preparations}}

Revision as of 12:22, 10 February 2014

Template:Oxetoron Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]

For patient information, click here.

Dimetotiazine
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • AU: <! -- A / B1 / B2 / B3 / C / D / X -->
  • US: <! -- A / B / C / D / X -->
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • AU: <! -- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
  • CA: <! -- Schedule I, II, III, IV, V, VI, VII, VIII -->
  • UK: <! -- GSL, P, POM, CD, or Class A, B, C -->
  • US: <! -- OTC / Rx-only / Schedule I, II, III, IV, V -->
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC19H25N3O2S2
Molar mass391.55 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)


Overview

Dimetotiazine (INN) is a phenothiazine. It is a serotonin antagonist and histamine antagonist.[1]


Category

Antimigraine agent

Template:Antimigraine preparations


Template:WH

Template:WS

  1. ↑ Shimazawa M, Hara H, Watano T, Sukamoto T (August 1995). "Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats". Br. J. Pharmacol. 115 (8): 1359–68. PMC 1908864. PMID 8564192.
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