Cholestyramine: Difference between revisions
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==Overview== | ==Overview== | ||
'''Cholestyramine''' or '''colestyramine''' ('''PREVALITE''', '''CHOLESTYRAMINE,CHOLESTYRAMINE LIGHT''') is a [[bile acid sequestrant]], which binds [[bile]] in the [[gastrointestinal tract]] to prevent its reabsorption. It is a strong [[ion exchange resin]], which means that it can exchange its [[chloride]] [[anion]]s with anionic [[bile acid]]s in the gastrointestinal tract and bind them strongly in the resin matrix. The functional group of the anion exchange resin is a [[quaternary ammonium|quaternary]] ammonium group attached to an inert [[styrene]]-[[divinylbenzene]] [[copolymer]]. | |||
Cholestyramine removes bile acids from the body by forming [[insoluble]] complexes with bile acids in the [[intestine]], which are then excreted in the [[feces]]. When bile acids are excreted, [[blood plasma|plasma]] [[cholesterol]] is converted to bile acid to normalize bile acid levels. This conversion of cholesterol into bile acids lowers plasma cholesterol levels. | |||
==Category== | ==Category== | ||
==FDA Package Insert== | ==FDA Package Insert== | ||
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==Mechanism of Action== | ==Mechanism of Action== | ||
== | ==External Links== | ||
[[{{PAGENAME}}#Publication Resources|Publication Resources]] | [[{{PAGENAME}}#Publication Resources|Publication Resources]] | ||
<br></font size><small>Recent articles, WikiDoc State of the Art Review, Textbook Information</small><font size="4"><br> | <br></font size><small>Recent articles, WikiDoc State of the Art Review, Textbook Information</small><font size="4"><br> | ||
[[{{PAGENAME}}#Media Resources|Media Resources]] | [[{{PAGENAME}}#Media Resources|Media Resources]] | ||
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[[{{PAGENAME}}#Patient Resources|Patient Resources]] | [[{{PAGENAME}}#Patient Resources|Patient Resources]] | ||
<br></font size><small>Discussion Groups, Handouts, Blogs, News, etc.</small><font size="4"><br> | <br></font size><small>Discussion Groups, Handouts, Blogs, News, etc.</small><font size="4"><br> | ||
[[{{PAGENAME}}#International Resources|International Resources]] | [[{{PAGENAME}}#International Resources|International Resources]] | ||
<br></font size><small>en Español</small><font size="4"><br> | <br></font size><small>en Español</small><font size="4"><br> | ||
==Publication Resources== | ==Publication Resources== | ||
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Most Recent Articles on {{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}] | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Most Recent Articles on{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}] | ||
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[http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}%20AND%20systematic%5Bsb%5D | [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}%20AND%20systematic%5Bsb%5D Review Articles on {{PAGENAME}}] | ||
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== | ==References== | ||
{{Reflist|2}} | |||
{{Lipid modifying agents}} | |||
[[Category:Hepatology]] | |||
[[Category:Bile acid sequestrants]] | |||
[[Category:Cardiovasuclar Drugs]] | |||
[[Category:Drugs]] | [[Category:Drugs]] |
Revision as of 15:38, 10 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
For patient information about Cholestyramine, click here.
Synonyms / Brand Names:
Overview
Cholestyramine or colestyramine (PREVALITE, CHOLESTYRAMINE,CHOLESTYRAMINE LIGHT) is a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption. It is a strong ion exchange resin, which means that it can exchange its chloride anions with anionic bile acids in the gastrointestinal tract and bind them strongly in the resin matrix. The functional group of the anion exchange resin is a quaternary ammonium group attached to an inert styrene-divinylbenzene copolymer.
Cholestyramine removes bile acids from the body by forming insoluble complexes with bile acids in the intestine, which are then excreted in the feces. When bile acids are excreted, plasma cholesterol is converted to bile acid to normalize bile acid levels. This conversion of cholesterol into bile acids lowers plasma cholesterol levels.
Category
FDA Package Insert
Indications and Usage | Dosage and Administration | Dosage Forms and Strengths | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages
Mechanism of Action
External Links
Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information
Media Resources
Slides, Video, Images, MP3, Podcasts, etc.
Patient Resources
Discussion Groups, Handouts, Blogs, News, etc.
International Resources
en Español
Publication Resources
Most Recent Articles onCholestyramine
Review Articles on Cholestyramine
Articles on Cholestyramine in N Eng J Med, Lancet, BMJ
WikiDoc State of the Art Review
Textbook Information onCholestyramine