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Revision as of 19:13, 12 February 2014
Synonyms / Brand Names: Neurontin
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Dosing and Administration
Gabapentin is given orally with or without food. Half-tablets not used within several days of breaking the scored tablet should be discarded.
Postherpetic Neuralgia: a single 300-mg dose on Day 1, 600 mg/day on Day 2 (divided BID), and 900 mg/day on Day 3 (divided TID). The dose can subsequently be titrated up as needed for pain relief to a daily dose of 1800 mg (divided TID).
Epilepsy: For age 12+, 900 to 1800 mg/day in divided dosage, starting at 300mg TID. For ages 3-12, 10–15 mg/kg/day in 3 divided doses, and the effective dose reached by increasing over 3 days. (effective dose for age 5+:25–35 mg/kg/day divided TID; age 3-4: 40 mg/kg/day divided TID)
Dosage in the elderly:Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and dose should be adjusted based on creatinine clearance values in these patients.
FDA Package Insert Resources
Indications, Contraindications, Side Effects, Drug Interactions, etc.
Calculate Creatine Clearance
On line calculator of your patients Cr Cl by a variety of formulas.
Convert pounds to Kilograms
On line calculator of your patients weight in pounds to Kg for dosing estimates.
Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information
Trial Resources
Ongoing Trials, Trial Results
Guidelines & Evidence Based Medicine Resources
US National Guidelines, Cochrane Collaboration, etc.
Media Resources
Slides, Video, Images, MP3, Podcasts, etc.
Patient Resources
Discussion Groups, Handouts, Blogs, News, etc.
International Resources
en Español
FDA Package Insert Resources
Indications
Contraindications
Side Effects
Drug Interactions
Precautions
Overdose
Instructions for Administration
How Supplied
Pharmacokinetics and Molecular Data
FDA label
FDA on Gabapentin
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Publication Resources
Most Recent Articles on Gabapentin
Review Articles on Gabapentin
Articles on Gabapentin in N Eng J Med, Lancet, BMJ
WikiDoc State of the Art Review
Textbook Information on Gabapentin
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Trial Resources
Ongoing Trials with Gabapentin at Clinical Trials.gov
Trial Results with Gabapentin
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Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Gabapentin
Cochrane Collaboration on Gabapentin
Cost Effectiveness of Gabapentin
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Media Resources
Powerpoint Slides on Gabapentin
Images of Gabapentin
Podcasts & MP3s on Gabapentin
Videos on Gabapentin
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Patient Resources
Patient Information from National Library of Medicine
Patient Resources on Gabapentin
Discussion Groups on Gabapentin
Patient Handouts on Gabapentin
Blogs on Gabapentin
Gabapentin in the News
Gabapentin in the Marketplace
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International Resources
Gabapentin en Español
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Adapted from the FDA Package Insert.