Protriptyline

Protriptyline
VIVACTIL (protriptyline hydrochloride) tablet® FDA Package Insert
Indications and Usage
Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
Clinical Studies
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
Clinical Trials on Protriptyline
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]

For patient information about Protriptyline, click here.

Synonyms / Brand Names: Vivactil®^®

Overview

Protriptyline

File:Protriptyline.png
Clinical data
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Oral
ATC code	N06AA11 (WHO)
Legal status
Legal status	Schedule VI (US)
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	54-92 hours
Excretion	Renal, in urine
Identifiers
IUPAC name N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine
CAS Number	438-60-8
PubChem CID	4976
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C19H21N
Molar mass	263.377 g/mol

Protriptyline is a tricyclic antidepressant (TCA), specifically a secondary amine, indicated for depression and ADHD. Unique among the tricyclics, protriptyline tends to be energizing instead of sedating, and it is sometimes used in narcolepsy to achieve a wakefulness-promoting effect. (The other TCAs tend to be sedating and therefore are often taken in the evening.)

Tricyclics including protriptyline are also used to reduce the incidence of recurring headaches such as migraine, and for other types of chronic pain.

VIVACTIL (protriptyline hydrochloride) tablet

Indications and Usage | Dosage and Administration | Dosage Forms and Strengths | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages

Mechanism of Action

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