Lisinopril indications and usage: Difference between revisions

Revision as of 20:22, 13 February 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2], Amr Marawan, M.D. [3]

Lisinopril

Lisinopril tablet

Lisinopril and Hydrochlorothiazide tablet

Lisinopril and Hydrochlorothiazide tablet

Overview

Lisinopril tablet is an angiontensin converting enzyme inhibitor drug that is FDA approved for the treatment of hypertension, heart failure, left ventricular dysfunction after myocardial infarction, diabetic nephropathy. Adverse reactions include hypotension, rash, hyperkalemia, disorder of taste, cough. hypotension, rash, hyperkalemia, disorder of taste, cough.

Indications and Usage

Hypertension

Lisinopril tablets are indicated for the treatment of hypertension. They may be used alone as initial therapy or concomitantly with other classes of antihypertensive agents.

Heart Failure

Lisinopril tablets are indicated as adjunctive therapy in the management of heart failure in patients who are not responding adequately to diuretics and digitalis.

Acute Myocardial Infarction

Lisinopril tablets are indicated for the treatment of hemodynamically stable patients within 24 hours of acute myocardial infarction, to improve survival. Patients should receive, as appropriate, the standard recommended treatments such as thrombolytics, aspirin, and beta-blockers.

In using lisinopril tablets, consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that lisinopril tablets do not have a similar risk.

In considering the use of lisinopril tablets, it should be noted that in controlled trials ACE inhibitors have an effect on blood pressure that is less in black patients than in non-blacks. In addition, ACE inhibitors have been associated with a higher rate of angioedema in black than in nonblack patients.^[1]

References

↑ "LISINOPRIL (LISINOPRIL) TABLET [LEK PHARMACEUTICALS]".

Adapted from the FDA Package Insert.

[dailymed.nlm.nih.gov-1] "LISINOPRIL (LISINOPRIL) TABLET [LEK PHARMACEUTICALS]".

[1]

@@ Line 3: / Line 3: @@
 {{CMG}}; {{AE}} {{AM}}
+==Indications and Usage==
+====Hypertension====
-<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = LISINOPRIL (LISINOPRIL) TABLET [LEK PHARMACEUTICALS] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=27ccb2f4-abf8-4825-9b05-0bb367b4ac07 | publisher =  | date =  | accessdate = }}</ref>
+Lisinopril tablets are indicated for the treatment of [[hypertension]]. They may be used alone as initial therapy or concomitantly with other classes of antihypertensive agents.
-==References==
+====Heart Failure====
-{{Reflist}}
-{{FDA}}
+Lisinopril tablets are indicated as adjunctive therapy in the management of [[heart failure]] in patients who are not responding adequately to [[diuretics]] and [[digitalis]].
-[[Category:Cardiovascular Drugs]]
+====Acute Myocardial Infarction====
-[[Category:Drugs]]
-==Hypertension==
+Lisinopril tablets are indicated for the treatment of hemodynamically stable patients within 24 hours of [[acute myocardial infarction]], to improve survival. Patients should receive, as appropriate, the standard recommended treatments such as [[thrombolytics]], [[aspirin]], and [[beta-blockers]].
-Lisinopril is indicated for the treatment of hypertension. It may be used alone as initial therapy or concomitantly with other classes of antihypertensive agents.
+In using lisinopril tablets, consideration should be given to the fact that another angiotensin converting enzyme inhibitor, [[captopril]], has caused [[agranulocytosis]], particularly in patients with renal impairment or [[collagen vascular disease]], and that available data are insufficient to show that lisinopril tablets do not have a similar risk.
-==Heart Failure==
+In considering the use of lisinopril tablets, it should be noted that in controlled trials ACE inhibitors have an effect on blood pressure that is less in black patients than in non-blacks. In addition, ACE inhibitors have been associated with a higher rate of [[angioedema]] in black than in nonblack patients.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = LISINOPRIL (LISINOPRIL) TABLET [LEK PHARMACEUTICALS] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=27ccb2f4-abf8-4825-9b05-0bb367b4ac07 | publisher =  | date =  | accessdate = }}</ref>
-Lisinopril is indicated as adjunctive therapy in the management of heart failure in patients who are not responding adequately to diuretics and digitalis.
+==References==
+{{Reflist}}
-==Acute Myocardial Infarction==
+{{FDA}}
-Lisinopril is indicated for the treatment of hemodynamically stable patients within 24 hours of acute myocardial infarction, to improve survival. Patients should receive, as appropriate, the standard recommended treatments such as thrombolytics, aspirin and beta-blockers.
+[[Category:Cardiovascular Drugs]]
-In using lisinopril, consideration should be given to the fact that another angiotensin-converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that lisinopril does not have a similar risk.
+[[Category:Drugs]]
-In considering the use of lisinopril, it should be noted that in controlled clinical trials ACE inhibitors have an effect on blood pressure that is less in Black patients than in non-Blacks. In addition, ACE inhibitors have been associated with a higher rate of angioedema in Black than in non-Black patients.