Multiple myeloma physical examination: Difference between revisions
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{{Multiple myeloma}} | {{Multiple myeloma}} | ||
Head, ears, eyes, nose, and throat (HEENT) examination: Pallor is one of the most evident physical findings associated with multiple myeloma. Additionally eyes may show exudative macular detachment, retinal hemorrhage, or cotton-wool spots. Ecchymoses or purpura from thrombocytopenia may be evident. | |||
Central nervous system: It includes altered sensations, dermatomal sensory loss resulting from cord compression and neuropathy, myopathy, a Tinel sign, or a Phalen sign due to carpel tunnel compression secondary to amyloid deposition. | |||
Gastrointestinal system: Hepatosplenomegaly | |||
Cardiovascular system: Cardiomyopathy from plasma protein deposition. | |||
Bony and muscular system: Pain without tenderness is a feature highly specific for multiple myeloma, though not diagnostic. Pathological fractures are also pretty common. | |||
Extramedullary plasmacytomas, which consist of soft-tissue masses of plasma cells, are not uncommon. | |||
Amyloidosis may develop in some patients with MM. The characteristic physical examination findings that suggest amyloidosis include the following: | |||
:* Shoulder pad sign | |||
:* Macroglossia | |||
:* Purpura | |||
:* Carpal tunnel syndrome | |||
== References == | == References == | ||
Revision as of 04:09, 17 February 2014
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Head, ears, eyes, nose, and throat (HEENT) examination: Pallor is one of the most evident physical findings associated with multiple myeloma. Additionally eyes may show exudative macular detachment, retinal hemorrhage, or cotton-wool spots. Ecchymoses or purpura from thrombocytopenia may be evident.
Central nervous system: It includes altered sensations, dermatomal sensory loss resulting from cord compression and neuropathy, myopathy, a Tinel sign, or a Phalen sign due to carpel tunnel compression secondary to amyloid deposition.
Gastrointestinal system: Hepatosplenomegaly
Cardiovascular system: Cardiomyopathy from plasma protein deposition.
Bony and muscular system: Pain without tenderness is a feature highly specific for multiple myeloma, though not diagnostic. Pathological fractures are also pretty common.
Extramedullary plasmacytomas, which consist of soft-tissue masses of plasma cells, are not uncommon.
Amyloidosis may develop in some patients with MM. The characteristic physical examination findings that suggest amyloidosis include the following:
- Shoulder pad sign
- Macroglossia
- Purpura
- Carpal tunnel syndrome
References