Multiple myeloma physical examination: Difference between revisions
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{{Multiple myeloma}} | {{Multiple myeloma}} | ||
'''Head, ears, eyes, nose, and throat (HEENT) examination:''' Pallor is one of the most evident physical findings associated with multiple myeloma. Additionally eyes may show exudative macular detachment, retinal hemorrhage, or cotton-wool spots | '''Head, ears, eyes, nose, and throat (HEENT) examination:''' [[Pallor]] is one of the most evident physical findings associated with multiple myeloma. Additionally eyes may show exudative macular detachment, [[retinal hemorrhage]], or [[cotton wool spot|cotton-wool spots]]. | ||
''' | '''Skin:''' [[Ecchymoses]] or [[purpura]] from [[thrombocytopenia]] may be evident. | ||
''' | '''Central nervous system:''' It includes altered sensations, dermatomal sensory loss resulting from [[cord compression]] and neuropathy, myopathy, a [[Tinel sign]], or a [[Phalen sign]] due to [[carpel tunnel syndrome|carpel tunnel compression]] secondary to [[amyloid]] deposition. | ||
'''Cardiovascular system:''' Cardiomyopathy from plasma protein deposition. | '''Gastrointestinal system:''' [[Hepatosplenomegaly]] | ||
'''Cardiovascular system:''' [[Cardiomyopathy]] from plasma protein deposition. | |||
'''Bony and muscular system:''' Pain without tenderness is a feature highly specific for multiple myeloma, though not diagnostic. Pathological fractures are also pretty common. | '''Bony and muscular system:''' Pain without tenderness is a feature highly specific for multiple myeloma, though not diagnostic. Pathological fractures are also pretty common. | ||
Extramedullary plasmacytomas, which consist of soft-tissue masses of plasma cells, are not uncommon. | [[Plasmacytoma|Extramedullary plasmacytomas]], which consist of soft-tissue masses of plasma cells, are not uncommon. | ||
'''Amyloidosis''' may develop in some patients with MM. The characteristic physical examination findings that suggest amyloidosis include the following: | '''Amyloidosis''' may develop in some patients with MM. The characteristic physical examination findings that suggest amyloidosis include the following: | ||
:* Shoulder pad sign | :* Shoulder pad sign - Fat deposition around shoulders. | ||
:* Macroglossia | :* [[Macroglossia]] | ||
:* Purpura | :* [[Purpura]] | ||
:* Carpal tunnel syndrome | :* [[Carpal tunnel syndrome]] | ||
== References == | == References == | ||
Revision as of 17:47, 17 February 2014
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Risk calculators and risk factors for Multiple myeloma physical examination |
Head, ears, eyes, nose, and throat (HEENT) examination: Pallor is one of the most evident physical findings associated with multiple myeloma. Additionally eyes may show exudative macular detachment, retinal hemorrhage, or cotton-wool spots.
Skin: Ecchymoses or purpura from thrombocytopenia may be evident.
Central nervous system: It includes altered sensations, dermatomal sensory loss resulting from cord compression and neuropathy, myopathy, a Tinel sign, or a Phalen sign due to carpel tunnel compression secondary to amyloid deposition.
Gastrointestinal system: Hepatosplenomegaly
Cardiovascular system: Cardiomyopathy from plasma protein deposition.
Bony and muscular system: Pain without tenderness is a feature highly specific for multiple myeloma, though not diagnostic. Pathological fractures are also pretty common.
Extramedullary plasmacytomas, which consist of soft-tissue masses of plasma cells, are not uncommon.
Amyloidosis may develop in some patients with MM. The characteristic physical examination findings that suggest amyloidosis include the following:
- Shoulder pad sign - Fat deposition around shoulders.
- Macroglossia
- Purpura
- Carpal tunnel syndrome
References