Thymoma historical perspective: Difference between revisions
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==Historical Perspective== | |||
It has long been assumed | |||
that thymic epithelial cells originate from | |||
both the ectodermal and endodermal | |||
germ cell layers. However, a growing | |||
body of evidence suggests that the | |||
diverse thymic epithelial populations all | |||
develop from a common thymic epithelial | |||
stem cell of endodermal origin {181, 684}. | |||
This concept does not exclude the occurrence | |||
of more differentiated “committed | |||
stem cells” with medullary, cortical or | |||
other phenotypes {1671}. Tumours that | |||
we know as thymomas derive from thymic | |||
epithelium. In spite of morphological and | |||
immunological evidence for tumour differentiation | |||
towards a medullary or cortical | |||
epithelial phenotype, available data do | |||
not allow to unequivocally assign thymic | |||
tumours to defined functional and | |||
anatomical compartments of the normal | |||
thymus {1691}. | |||
<ref>{{Cite web | last = | first = | title = http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/BB10.pdf | url = http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/BB10.pdf | publisher = | date = | accessdate = }}</ref> | |||
==References== | ==References== | ||
Revision as of 17:37, 21 February 2014
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Thymoma Microchapters |
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Diagnosis |
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Case Studies |
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Thymoma historical perspective On the Web |
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American Roentgen Ray Society Images of Thymoma historical perspective |
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Risk calculators and risk factors for Thymoma historical perspective |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Amr Marawan, M.D. [2]
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Historical Perspective
It has long been assumed that thymic epithelial cells originate from both the ectodermal and endodermal germ cell layers. However, a growing body of evidence suggests that the diverse thymic epithelial populations all develop from a common thymic epithelial stem cell of endodermal origin {181, 684}. This concept does not exclude the occurrence of more differentiated “committed stem cells” with medullary, cortical or other phenotypes {1671}. Tumours that we know as thymomas derive from thymic epithelium. In spite of morphological and immunological evidence for tumour differentiation towards a medullary or cortical epithelial phenotype, available data do not allow to unequivocally assign thymic tumours to defined functional and anatomical compartments of the normal thymus {1691}. [1]
References
- ↑ "http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/BB10.pdf" (PDF). External link in
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