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| __NOTOC__
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| {{CMG}}; {{AE}}; {{chetan}}
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| ==Definition==
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| Acetaaminophen is widely used as a pain medication in the U.S . An overdose normally occurs when somebody ingests it accidentally or intentionally above the normal recommended dose . It one of the most common poisoning in the U.S and worldwide . The main reason of this being that is is easily available and people think that it is a very safe medication . It is available in the U.S market under the following brand names .
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| *[[Tylenol]]
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| *Anacin-3
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| *Liquiprin
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| *Percocet
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| *Tempra
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| *Cold and flu medicines.
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| *Aceta
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| *Actimin
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| *Apacet
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| *Aspirin Free Anacin
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| *Atasol
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| *Banesin
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| *Dapa
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| *Datril Extra-Strength
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| *Feverall
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| *Fibi
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| *Genapap
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| *Genebs,
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| *[[Panadol]]
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| ===Common dosage forms and strengths===
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| #Suppository: 120 mg, 125 mg, 325 mg, 650 mg
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| #Chewable tablets: 80 mg
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| #Regular strength: 325 mg
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| #Extra strength: 500 mg
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| #Liquid: 160 mg/teaspoon
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| #Drops: 100 mg / mL, 120 mg / 2.5 mL
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| '''mg = milligrams'''
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| Maximum advisable dosage is 4000 mg of acetaminophen a day . A severe overdose can happen if taken more than 7000 mg / day .
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| ==Causes/Pathophysiology==
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| After ingestion of an excessive amount of acetaminophen a toxic metabolite called '''N-acetyl-p-benzoquinonimine (NAPQI)''' is formed in excess and hence the normal pathways of conjugating by glutathione are saturated . This results in glutathione depletion which leads to liver injury .
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| ==Management==
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| Most of the patients who have an overdose of acetaminophen are asymptomatic . A few however who are symptomatic show symptoms only after 12 hrs of ingestion.
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| ==References==
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| [[Category:Toxicology]]
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| [[Category:Medicine]]
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| [[Category:Primary care]]
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| [[Category:Resident survival guide]]
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